10.1007/s40204-017-0075-9

Anisotropic dehydration of hydrogel surfaces

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  • Georgia Kaklamani1,
  • David Cheneler2,
  • Liam M. Grover3,
  • Michael J. Adams3,
  • Spiros H. Anastasiadis4,
  • James Bowen*5,
  1. Institute of Electronic Structure and Laser, Foundation for Research and Technology Hellas, Heraklion, Crete, GR
  2. Engineering Department, Lancaster University, Lancaster, LA1 4YR, GB
  3. School of Chemical Engineering, The University of Birmingham, Edgbaston, B15 2TT, GB
  4. Institute of Electronic Structure and Laser, Foundation for Research and Technology Hellas, Heraklion, Crete, GR Department of Chemistry, University of Crete, Heraklion, Crete, GR
  5. Department of Engineering and Innovation, The Open University, Milton Keynes, MK7 6AA, GB
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Published in Issue 2017-10-23

How to Cite

Kaklamani, G., Cheneler, D., Grover, L. M., Adams, M. J., Anastasiadis, S. H., & Bowen, J. (2017). Anisotropic dehydration of hydrogel surfaces. Progress in Biomaterials, 6(4 (December 2017). https://doi.org/10.1007/s40204-017-0075-9
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Abstract

Abstract Efforts to develop tissue-engineered skin for regenerative medicine have explored natural, synthetic, and hybrid hydrogels. The creation of a bilayer material, with the stratification exhibited by native skin, is a complex problem. The mechanically robust, waterproof epidermis presents the stratum corneum at the tissue/air interface, which confers many of these protective properties. In this work, we explore the effect of high temperatures on alginate hydrogels, which are widely employed for tissue engineering due to their excellent mechanical properties and cellular compatibility. In particular, we investigate the rapid dehydration of the hydrogel surface which occurs following local exposure to heated surfaces with temperatures in the range 100–200 °C. We report the creation of a mechanically strengthened hydrogel surface, with improved puncture resistance and increased coefficient of friction, compared to an unheated surface. The use of a mechanical restraint during heating promoted differences in the rate of mass loss; the rate of temperature increase within the hydrogel, in the presence and absence of restraint, is simulated and discussed. It is hoped that the results will be of use in the development of processes suitable for preparing skin-like analogues; application areas could include wound healing and skin restoration.

Keywords

  • Alginate,
  • Dehydration,
  • Hydrogel,
  • Polysaccharide,
  • Skin,
  • Stratification
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References

  1. Adams et al. (2007) Friction and lubrication of human skin (pp. 239-253) https://doi.org/10.1007/s11249-007-9206-0
  2. Adams et al. (2013) Finger pad friction and its role in grip and touch (pp. 1-19)
  3. Alsberg et al. (2001) Cell-interactive alginate hydrogels for bone tissue engineering (pp. 2025-2029) https://doi.org/10.1177/00220345010800111501
  4. Augst et al. (2006) Alginate hydrogels as biomaterials (pp. 623-633) https://doi.org/10.1002/mabi.200600069
  5. Bakakrishnan et al. (2005) Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin (pp. 6335-6342) https://doi.org/10.1016/j.biomaterials.2005.04.012
  6. Bannasch et al. (2003) Skin tissue engineering (pp. 573-579) https://doi.org/10.1016/S0094-1298(03)00075-0
  7. Bello et al. (2001) Tissue engineered skin (pp. 305-313) https://doi.org/10.2165/00128071-200102050-00005
  8. Boucard et al. (2007) The use of physical hydrogels of chitosan for skin regeneration following third-degree burns (pp. 3478-3488) https://doi.org/10.1016/j.biomaterials.2007.04.021
  9. Chan et al. (2002) Cross-linking mechanisms of calcium and zinc in production of alginate microspheres (pp. 255-258) https://doi.org/10.1016/S0378-5173(02)00169-2
  10. Chan et al. (2002) Production of alginate microspheres by internal gelation using an emulsification method (pp. 259-262) https://doi.org/10.1016/S0378-5173(02)00170-9
  11. Choi et al. (1999) Study on gelatin-containing artificial skin: I. Preparation and characteristics of novel gelatin-alginate sponge (pp. 409-417) https://doi.org/10.1016/S0142-9612(98)00180-X
  12. Currie et al. (2001) The use of fibrin glue in skin grafts and tissue-engineered skin replacements: a review (pp. 1713-1726) https://doi.org/10.1097/00006534-200111000-00045
  13. Dormer et al. (2010) Emerging techniques in stratified designs and continues gradients for tissue engineering of interfaces (pp. 2121-2141) https://doi.org/10.1007/s10439-010-0033-3
  14. Fuchs and Horsley (2008) More than one way to skin (pp. 976-985) https://doi.org/10.1101/gad.1645908
  15. Grossin et al. (2009) Step-by-step built-up of biologically active cell-containing stratified films aimed at tissue engineering (pp. 650-655) https://doi.org/10.1002/adma.200801541
  16. Horch et al. (2005) Tissue engineering of cultured skin substrates (pp. 592-608) https://doi.org/10.1111/j.1582-4934.2005.tb00491.x
  17. Hunt et al. (2009) An alginate hydrogels matrix for the localized delivery of a fibroblast/keratinocyte co-culture (pp. 730-737) https://doi.org/10.1002/biot.200800292
  18. Hunt et al. (2010) Encapsulation of fibroblasts causes accelerated alginate hydrogel degradation (pp. 3649-3656) https://doi.org/10.1016/j.actbio.2010.03.026
  19. Johnson et al. (1993) The friction and lubrication of human stratum corneum (pp. 663-672)
  20. Kaklamani et al. (2014) Mechanical properties of alginate hydrogels using external gelation (pp. 135-142) https://doi.org/10.1016/j.jmbbm.2014.04.013
  21. Kim et al. (2011) Coaxial structured collagen-alginate scaffolds: fabrication, physical properties, and biomedical application for skin tissue regeneration (pp. 6165-6172) https://doi.org/10.1039/c0jm03452e
  22. Lechler and Fuchs (2005) Asymmetric cell divisions promote stratification and differentiation of mammalian skin (pp. 275-280) https://doi.org/10.1038/nature03922
  23. Lee et al. (2009) Multi-layered culture of human skin fibroblasts and keratinocytes through three-dimensional freeform fabrication (pp. 1587-1595) https://doi.org/10.1016/j.biomaterials.2008.12.009
  24. MacNeil (2007) Progress and opportunities for tissue-engineered skin (pp. 874-880) https://doi.org/10.1038/nature05664
  25. Mao et al. (2003) Study of novel chitosan-gelatin artificial skin in vitro (pp. 301-308) https://doi.org/10.1002/jbm.a.10223
  26. Morch et al. (2006) Effect of Ca2+, Ba2+, and Sr2+ on alginate microbeads (pp. 1471-1480) https://doi.org/10.1021/bm060010d
  27. Powell and Boyce (2009) Engineered human skin fabricated using electrospun collagen-PCL blends: morphogenesis and mechanical properties (pp. 2177-2187) https://doi.org/10.1089/ten.tea.2008.0473
  28. Priya et al. (2008) Skin tissue engineering for tissue repair and regeneration (pp. 105-118) https://doi.org/10.1089/teb.2007.0318
  29. Shevchenko et al. (2010) A review of tissue-engineered skin bioconstructs available for skin reconstruction (pp. 229-258) https://doi.org/10.1098/rsif.2009.0403
  30. Stevens et al. (2004) A rapid-curing alginate gel system: utility in periosteum-derived cartilage tissue engineering (pp. 887-894) https://doi.org/10.1016/j.biomaterials.2003.07.002
  31. Topuz et al. (2012) Magnesium ions and alginate do form hydrogels: a rheological study (pp. 4877-4881) https://doi.org/10.1039/c2sm07465f
  32. VanGerwen et al. (2012) Needle–tissue interaction forces—a survey of experimental data (pp. 665-680) https://doi.org/10.1016/j.medengphy.2012.04.007
  33. Xie (2012) Interactive heat transfer simulations for everyone (pp. 237-240) https://doi.org/10.1119/1.3694080
  34. Yang et al. (2000) Tissue engineered artificial skin composed of dermis and epidermis (pp. 7-17) https://doi.org/10.1046/j.1525-1594.2000.06334.x