10.1007/s40204-017-0062-1

Designing and fabrication of curcumin loaded PCL/PVA multi-layer nanofibrous electrospun structures as active wound dressing

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  • Seyed Mahdi Saeed1,
  • Hamid Mirzadeh2,
  • Mojgan Zandi*1,
  • Jalal Barzin1,
  1. Department of Biomaterials, Iran Polymer and Petrochemical Institute, Tehran, IR
  2. Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, IR
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Published in Issue 2017-02-02

How to Cite

Saeed, S. M., Mirzadeh, H., Zandi, M., & Barzin, J. (2017). Designing and fabrication of curcumin loaded PCL/PVA multi-layer nanofibrous electrospun structures as active wound dressing. Progress in Biomaterials, 6(1-2 (May 2017). https://doi.org/10.1007/s40204-017-0062-1
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Abstract

Abstract Active wound dressings play a significant role in burn and chronic wound treatment. In this study, electrospinning process is used to fabricate a novel three-layer active wound dressing based on ε-polycaprolactone (PCL), polyvinylalcohol (PVA), and curcumin (CU) as a biologically active compound. The main purpose for developing such a system is to control wound exudates, which remains a challenge, as well as enjoying the anti-bacterial property. Electrospinning process parameters are optimized by response surface methodology to achieve appropriate nanofibrous electrospun mats, and then, a three-layer dressing has been designed in view of water absorbability, anti-bacterial, and biocompatibility characteristics of the final dressing. The results illustrate that a three-layer dressing based on PCL/curcumin containing PVA as a middle layer with optimized thickness which is placed over the incision, absorbs three times exudates in comparison with pristine dressing. Anti-bacterial tests reveal that the dressing containing 16% curcumin exhibits anti-bacterial activity without sacrificing the acceptable level of cell viability.

Keywords

  • Electrospinning,
  • Nanofibers,
  • Wound dressing,
  • Response surface
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