10.1007/s40204-015-0043-1

Influence of temperature, pH and simulated biological solutions on swelling and structural properties of biomineralized (CaCO3) PVP–CMC hydrogel

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  • Rushita Shah1,
  • Nabanita Saha*1,
  • Petr Saha1,
  1. Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Zlin, 760 01, CZ
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Published in Issue 2015-11-02

How to Cite

Shah, R., Saha, N., & Saha, P. (2015). Influence of temperature, pH and simulated biological solutions on swelling and structural properties of biomineralized (CaCO3) PVP–CMC hydrogel. Progress in Biomaterials, 4(2-4 (December 2015). https://doi.org/10.1007/s40204-015-0043-1
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Abstract

Abstract Biomaterials having stimuli response are interesting in the biomedical field. This paper reports about swelling response and internal structural of biomineralized (CaCO 3 ) polyvinylpyrrolidone (PVP) carboxymethylcellulose (CMC) hydrogel having various thicknesses (0.1–0.4 mm). Samples were tested in aqueous solution using temperature ranges from 10 to 40 °C; pH varies from 4 to 9, time 60 min. In addition, an experiment was conducted in the presence of simulated biological solutions (SBS): glucose (GS), physiological fluid (PS) and urea (US) at temperature 37 °C and pH 7.5 for 180 min. It is noticed that the maximum swelling ratio reached in 30–40 °C at pH 7 in aqueous solution. Among biological fluids, the swelling ratio shows: US > PS > GS at temperature 37 °C, pH 7.5, time 150 min. The equilibrium swelling ratio of the test sample in SBS and their non-reformative apparent structure confirm that biomineralized (CaCO 3 ) PVP–CMC hydrogel can be acclaimed for medical application like bone tissue engineering. Graphical Abstract

Keywords

  • Biomineralization,
  • Swelling,
  • Stimulus,
  • Simulated biological solutions,
  • Equilibrium swelling ratio
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