10.1007/s40204-022-00204-8

Synthesis, physical properties, and biomedical applications of magnetic nanoparticles: a review

  • Sunita Keshri*1,
  • Sonali Biswas2,
  1. Department of Physics, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, IN
  2. Department of Engineering Physics, College of Engineering, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, 522302, IN

Published in Issue 2022-09-26

How to Cite

Keshri, S., & Biswas, S. (2022). Synthesis, physical properties, and biomedical applications of magnetic nanoparticles: a review. Progress in Biomaterials, 11(4 (December 2022). https://doi.org/10.1007/s40204-022-00204-8
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Abstract

Abstract Recent innovations in nanotechnology have opened the applicability of multifunctional nanoparticles (NPs) in biomedical diagnosis and treatment. The examples of NPs which have attracted considerable attention in recent years are metals (e.g., Au, Ag, Mg), alloys (e.g., Fe–Co, Fe–Pd, Fe–Pt, Co–Pt), iron oxides (e.g., Fe 2 O 3 and Fe 3 O 4 ), substituted ferrites (e.g., MnFe 2 O 4 and CoFe 2 O 4 ), manganites (e.g., La0.67Sr0.33MnO3\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathrm{La}}_{0.67}{\mathrm{Sr}}_{0.33}{\mathrm{MnO}}_{3}$$\end{document} ), etc. Special attention has been paid to magnetic NPs (MNPs), as they are the potential candidates for several biomedical appliances, such as hyperthermia applications, magnetic resonance imaging, contrast imaging, and drug delivery. To achieve effective MNPs, a thorough investigation on the synthesis, and characteristic properties, including size, magnetic properties, and toxicity, is required. Furthermore, the surfaces of the NPs must be tailored to improve the biocompatibility properties and reduce agglomeration. The present review focuses on different mechanisms to develop biocompatible MNPs. The utility of these MNPs in various biomedical applications, especially in treating and diagnosing human diseases, such as targeted drug delivery, hyperthermia treatment for cancer, and other biomedical diagnoses, is thoroughly discussed in this article. Different synthetic processes and important physical properties of these MNPs and their biocomposites are presented.

Keywords

  • Magnetic nanoparticles,
  • Iron oxides,
  • Ferrites,
  • Manganites,
  • MR,
  • Hyperthermia,
  • Drug delivery

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