10.1007/s40204-022-00189-4

Progress in manufacturing and processing of degradable Fe-based implants: a review

  • V. P. Muhammad Rabeeh1,
  • T. Hanas*2,
  1. Nanomaterials Research Laboratory, School of Materials Science and Engineering, National Institute of Technology Calicut, Kozhikode, 673601, IN
  2. Nanomaterials Research Laboratory, School of Materials Science and Engineering, National Institute of Technology Calicut, Kozhikode, 673601, IN Department of Mechanical Engineering, National Institute of Technology Calicut, Kozhikode, 673601, IN

Published in Issue 2022-05-18

How to Cite

Rabeeh, V. P. M., & Hanas, T. (2022). Progress in manufacturing and processing of degradable Fe-based implants: a review. Progress in Biomaterials, 11(2 (June 2022). https://doi.org/10.1007/s40204-022-00189-4
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Abstract

Abstract Biodegradable metals have gained vast attention as befitting candidates for developing degradable metallic implants. Such implants are primarily employed for temporary applications and are expected to degrade or resorbed after the tissue is healed. Fe-based materials have generated considerable interest as one of the possible biodegradable metals. Like other biometals such as Mg and Zn, Fe exhibits good biocompatibility and biodegradability. The versatility in the mechanical behaviour of Fe-based materials makes them a better choice for load-bearing applications. However, the very low degradation rate of Fe in the physiological environment needs to be improved to make it compatible with tissue growth. Several studies on tailoring the degradation behaviour of Fe in the human body are already reported. Majority of these works include studies on the effect of manufacturing and processing techniques on biocompatibility and biodegradability. This article focuses on a comprehensive review and analysis of the various manufacturing and processing techniques so far reported for developing biodegradable iron-based orthopaedic implants. The current status of research in the field is neatly presented, and a summary of the works is included in the article for the benefit of researchers in the field to contextualise their research and effectively find the lacunae in the existing scholarship.

Keywords

  • Iron,
  • Biodegradable metals,
  • Surface modification,
  • In vitro,
  • Orthopaedic implant,
  • Biomaterials,
  • Biometals

References

  1. Adhilakshmi et al. (2020) Cathodic electrodeposition of zinc-zinc phosphate-calcium phosphate composite coatings on pure iron for biodegradable implant applications (pp. 6475-6489) https://doi.org/10.1039/d0nj00991a
  2. Al-Amin et al. (2020) Bio-ceramic coatings adhesion and roughness of biomaterials through PM-EDM: a comprehensive review https://doi.org/10.1080/10426914.2020.1772483
  3. Ansari (2019) Bone tissue regeneration: biology, strategies and interface studies (pp. 223-237) https://doi.org/10.1007/S40204-019-00125-Z
  4. Aschner et al. (2007) Manganese: recent advances in understanding its transport and neurotoxicity (pp. 131-147) https://doi.org/10.1016/j.taap.2007.03.001
  5. Bauer et al. (2013) Engineering biocompatible implant surfaces: Part I: materials and surfaces (pp. 261-326) https://doi.org/10.1016/j.pmatsci.2012.09.001
  6. Beattie and Avenell (1992) Trace element nutrition and bone metabolism (pp. 167-188) https://doi.org/10.1079/nrr19920013
  7. Bosetti et al. (2002) Silver coated materials for external fixation devices: in vitro biocompatibility and genotoxicity (pp. 887-892) https://doi.org/10.1016/S0142-9612(01)00198-3
  8. Brooks et al. (1970) The biomechanics of torsional fractures. The stress concentration effect of a drill hole (pp. 507-514) https://doi.org/10.2106/00004623-197052030-00008
  9. Čapek and Vojtěch (2014) Microstructural and mechanical characteristics of porous iron prepared by powder metallurgy (pp. 494-501) https://doi.org/10.1016/j.msec.2014.06.046
  10. Čapek et al. (2016) Microstructural, mechanical, corrosion and cytotoxicity characterization of the hot forged FeMn30 (% by wt) alloy (pp. 900-908) https://doi.org/10.1016/j.msec.2015.09.049
  11. Čapek et al. (2016) Microstructure, mechanical and corrosion properties of biodegradable powder metallurgical Fe-2 wt% X (X = Pd, Ag and C) alloys (pp. 501-511) https://doi.org/10.1016/j.matchemphys.2016.06.087
  12. Čapek et al. (2017) A novel high-strength and highly corrosive biodegradable Fe-Pd alloy: structural, mechanical and in vitro corrosion and cytotoxicity study (pp. 550-562) https://doi.org/10.1016/j.msec.2017.05.100
  13. Carluccio et al. (2020) Additively manufactured iron-manganese for biodegradable porous load-bearing bone scaffold applications (pp. 346-360) https://doi.org/10.1016/j.actbio.2019.12.018
  14. Chaturvedi (2013) Allergy related to dental implant and its clinical significance (pp. 57-61) https://doi.org/10.2147/CCIDE.S35170
  15. Chen and Thouas (2015) Metallic implant biomaterials (pp. 1-57) https://doi.org/10.1016/j.mser.2014.10.001
  16. Chen et al. (2008) The microstructure and properties of commercial pure iron modified by plasma nitriding (pp. 971-974) https://doi.org/10.1016/j.ssi.2008.03.019
  17. Cheng and Zheng (2013) In vitro study on newly designed biodegradable Fe-X composites (X = W, CNT) prepared by spark plasma sintering (pp. 485-497) https://doi.org/10.1002/jbm.b.32783
  18. Cheng et al. (2013) Comparative invitro study on pure metals (Fe, Mn, Mg, Zn and W) as biodegradable metals (pp. 619-627) https://doi.org/10.1016/j.jmst.2013.03.019
  19. Cheng et al. (2014) a. Microstructure, mechanical property, biodegradation behavior, and biocompatibility of biodegradable Fe–Fe2O3 composites (pp. 2277-2287) https://doi.org/10.1002/jbm.a.34882
  20. Cheng et al. (2015) Relatively uniform and accelerated degradation of pure iron coated with micro-patterned Au disc arrays (pp. 679-687) https://doi.org/10.1016/j.msec.2014.12.053
  21. Chou et al. (2013) Novel processing of iron-manganese alloy-based biomaterials by inkjet 3-D printing (pp. 8593-8603) https://doi.org/10.1016/j.actbio.2013.04.016
  22. Crangle (2006) Ferromagnetism in Pd-rich palladium-iron alloys (pp. 335-342) https://doi.org/10.1080/14786436008235850
  23. Crossgrove and Zheng (2004) Manganese toxicity upon overexposure (pp. 544-553) https://doi.org/10.1002/nbm.931
  24. Dehestani et al. (2016) Mechanical properties and corrosion behavior of powder metallurgy iron-hydroxyapatite composites for biodegradable implant applications (pp. 556-569) https://doi.org/10.1016/j.matdes.2016.07.092
  25. Dehestani et al. (2017) Effects of microstructure and heat treatment on mechanical properties and corrosion behavior of powder metallurgy derived Fe–30Mn alloy (pp. 214-226) https://doi.org/10.1016/j.msea.2017.07.054
  26. Dehghan-Manshadi et al. (2019) Tensile properties and fracture behaviour of biodegradable iron-manganese scaffolds produced by powder sintering https://doi.org/10.3390/ma12101572
  27. Donik et al. (2018) Improved biodegradability of Fe–Mn alloy after modification of surface chemistry and topography by a laser ablation (pp. 383-393) https://doi.org/10.1016/j.apsusc.2018.05.066
  28. Dorozhkin (2014) Calcium orthophosphate coatings on magnesium and its biodegradable alloys (pp. 2919-2934) https://doi.org/10.1016/J.ACTBIO.2014.02.026
  29. Drevet et al. (2018) Martensitic transformations and mechanical and corrosion properties of Fe–Mn–Si alloys for biodegradable medical implants (pp. 1006-1013) https://doi.org/10.1007/s11661-017-4458-2
  30. Drynda et al. (2015) In vitro and in vivo corrosion properties of new iron-manganese alloys designed for cardiovascular applications (pp. 649-660) https://doi.org/10.1002/jbm.b.33234
  31. Fântânariu et al. (2015) A new Fe–Mn–Si alloplastic biomaterial as bone grafting material: in vivo study (pp. 129-139) https://doi.org/10.1016/J.APSUSC.2015.04.197
  32. Feng et al. (2013) Characterization and in vivo evaluation of a bio-corrodible nitrided iron stent (pp. 713-724) https://doi.org/10.1007/s10856-012-4823-z
  33. Gao et al. (2017) Shuai C (2017) Bone biomaterials and interactions with stem cells 51(5) (pp. 1-33) https://doi.org/10.1038/boneres.2017.59
  34. Gao et al. (2020) Peng S (2020) Advances in biocermets for bone implant applications 34(3) (pp. 307-330) https://doi.org/10.1007/S42242-020-00087-3
  35. Garimella et al. (2019) An integrated approach to develop engineered metal composite bone scaffold with controlled degradation (pp. 858-866) https://doi.org/10.1080/10667857.2019.1639004
  36. Geurtsen (2002) Biocompatibility of dental casting alloys (pp. 71-84) https://doi.org/10.1177/154411130201300108
  37. Gierl-Mayer (2020) Reactions between ferrous powder compacts and atmospheres during sintering—an overview (pp. 237-253) https://doi.org/10.1080/00325899.2020.1810427
  38. Gorejová et al. (2020) In vitro corrosion behavior of biodegradable iron foams with polymeric coating (pp. 1-17) https://doi.org/10.3390/ma13010184
  39. Hanas et al. (2018) Electrospun PCL/HA coated friction stir processed AZ31/HA composites for degradable implant applications (pp. 398-406) https://doi.org/10.1016/J.JMATPROTEC.2017.10.009
  40. Haverová et al. (2018) An in vitro corrosion study of open cell Iron structures with PEG coating for bone replacement applications (pp. 1-21) https://doi.org/10.3390/met8070499
  41. He et al. (2016) Advances in Fe-based biodegradable metallic materials https://doi.org/10.1039/c6ra20594a
  42. He et al. (2016) A novel porous Fe/Fe-W alloy scaffold with a double-layer structured skeleton: Preparation, in vitro degradability and biocompatibility (pp. 325-333) https://doi.org/10.1016/j.colsurfb.2016.03.002
  43. He et al. (2019) Cancellous-bone-like porous iron scaffold coated with strontium incorporated octacalcium phosphate nanowhiskers for bone regeneration (pp. 509-518) https://doi.org/10.1021/acsbiomaterials.8b01188
  44. Heiden et al. (2015) Evolution of novel bioresorbable iron-manganese implant surfaces and their degradation behaviors in vitro (pp. 185-193) https://doi.org/10.1002/jbm.a.35155
  45. Heiden et al. (2017) Bioresorbable Fe–Mn and Fe–Mn–HA materials for orthopedic implantation: enhancing degradation through porosity control https://doi.org/10.1002/ADHM.201700120
  46. Hermawan (2018) Updates on the research and development of absorbable metals for biomedical applications (pp. 93-110) https://doi.org/10.1007/S40204-018-0091-4
  47. Hermawan and Mantovani (2013) Process of prototyping coronary stents from biodegradable Fe–Mn alloys (pp. 8585-8592) https://doi.org/10.1016/j.actbio.2013.04.027
  48. Hermawan et al. (2007) Development of degradable Fe–35Mn alloy for biomedical application (pp. 107-112) https://doi.org/10.4028/www.scientific.net/AMR.15-17.107
  49. Hermawan et al. (2008) Iron–manganese: new class of metallic degradable biomaterials prepared by powder metallurgy (pp. 38-45) https://doi.org/10.1179/174329008X284868
  50. Hermawan et al. (2010) Degradable metallic biomaterials for cardiovascular applications (pp. 379-404) Elsevier https://doi.org/10.1533/9781845699246.4.379
  51. Hermawan et al. (2010) Degradable metallic biomaterials: design and development of Fe–Mn alloys for stents (pp. 1-11) https://doi.org/10.1002/jbm.a.32224
  52. Hermawan et al. (2010) Fe–Mn alloys for metallic biodegradable stents: degradation and cell viability studies (pp. 1852-1860) https://doi.org/10.1016/j.actbio.2009.11.025
  53. Hočevar et al. (2017) Corrosion on polished and laser-textured surfaces of An Fe–Mn biodegradable alloy (pp. 1037-1041) https://doi.org/10.17222/mit.2017.140
  54. Hong et al. (2016) Binder-jetting 3D printing and alloy development of new biodegradable Fe-Mn-Ca/Mg alloys (pp. 375-386) https://doi.org/10.1016/j.actbio.2016.08.032
  55. Hrubovčáková et al. (2017) Biodegradable polylactic acid and polylactic acid/hydroxyapatite coated iron foams for bone replacement materials (pp. 11122-11136) https://doi.org/10.20964/2017.12.53
  56. Huang and Zheng (2016) Uniform and accelerated degradation of pure iron patterned by Pt disc arrays https://doi.org/10.1038/srep23627
  57. Huang et al. (2014) In vitro degradation and biocompatibility of Fe-Pd and Fe-Pt composites fabricated by spark plasma sintering (pp. 43-53) https://doi.org/10.1016/j.msec.2013.10.023
  58. Huang et al. (2016) Fe-Au and Fe-Ag composites as candidates for biodegradable stent materials (pp. 225-240) https://doi.org/10.1002/jbm.b.33389
  59. Huang et al. (2016) In vitro studies on silver implanted pure iron by metal vapor vacuum arc technique (pp. 20-29) https://doi.org/10.1016/j.colsurfb.2016.01.065
  60. Huang et al. (2016) Accelerating degradation rate of pure iron by zinc ion implantation (pp. 205-215) https://doi.org/10.1093/rb/rbw020
  61. Huang et al. (2020) Collagen coating effects on Fe–Mn bioresorbable alloys (pp. 523-535) https://doi.org/10.1002/JOR.24492
  62. Huang et al. (2021) Tailoring grain sizes of the biodegradable iron-based alloys by pre-additive manufacturing microalloying https://doi.org/10.1038/S41598-021-89022-9
  63. Hufenbach et al. (2017) Novel biodegradable Fe-Mn-C-S alloy with superior mechanical and corrosion properties (pp. 330-333) https://doi.org/10.1016/j.matlet.2016.10.037
  64. Hufenbach et al. (2018) S and B microalloying of biodegradable Fe-30Mn-1C—effects on microstructure, tensile properties, in vitro degradation and cytotoxicity (pp. 22-35) https://doi.org/10.1016/j.matdes.2018.01.005
  65. Ito et al. (2015) Metallic biomaterials in orthopedic surgery (pp. 213-231) Springer
  66. Jiang et al. (2021) Additive manufacturing of biodegradable iron-based particle reinforced polylactic acid composite scaffolds for tissue engineering https://doi.org/10.1016/J.JMATPROTEC.2020.116952
  67. Jurgeleit et al. (2015) Magnetron sputtering a new fabrication method of iron based biodegradable implant materials (pp. 1-9) https://doi.org/10.1155/2015/294686
  68. Jurgeleit et al. (2016) Mechanical properties and in vitro degradation of sputtered biodegradable Fe–Au foils https://doi.org/10.3390/ma9110928
  69. Kabir et al. (2021) Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: biomechanical and biocorrosion perspectives (pp. 836-879) https://doi.org/10.1016/J.BIOACTMAT.2020.09.013
  70. Kirchhoff et al. (2008) Outcome analysis following removal of locking plate fixation of the proximal humerus https://doi.org/10.1186/1471-2474-9-138
  71. Kraus et al. (2014) Biodegradable Fe-based alloys for use in osteosynthesis: outcome of an in vivo study after 52 weeks (pp. 3346-3353) https://doi.org/10.1016/j.actbio.2014.04.007
  72. Kumar et al. (2019) Processing of titanium-based human implant material using wire EDM (pp. 695-700) https://doi.org/10.1080/10426914.2019.1566609
  73. Lee et al. (2021) Accelerated biodegradation of iron-based implants via tantalum-implanted surface nanostructures 10(9) (pp. 239-250) https://doi.org/10.1016/J.BIOACTMAT.2021.07.003
  74. Leo Kumar and Avinash (2020) Review on effect of Ti-alloy processing techniques on surface-integrity for biomedical application (pp. 869-892) https://doi.org/10.1080/10426914.2020.1748195
  75. Lévesque et al. (2008) Design of a pseudo-physiological test bench specific to the development of biodegradable metallic biomaterials (pp. 284-295) https://doi.org/10.1016/j.actbio.2007.09.012
  76. Li et al. (2018) Additively manufactured biodegradable porous iron (pp. 380-393) https://doi.org/10.1016/j.actbio.2018.07.011
  77. Li et al. (2019) Design of biodegradable, implantable devices towards clinical translation 51(5) (pp. 61-81) https://doi.org/10.1038/s41578-019-0150-z
  78. Li et al. (2019) Challenges in the use of zinc and its alloys as biodegradable metals: perspective from biomechanical compatibility (pp. 23-45) https://doi.org/10.1016/J.ACTBIO.2019.07.038
  79. Li et al. (2019) Additively manufactured functionally graded biodegradable porous iron (pp. 646-661) https://doi.org/10.1016/j.actbio.2019.07.013
  80. Li et al. (2021) Atomic layer deposition of zinc oxide onto 3D porous iron scaffolds for bone repair: in vitro degradation, antibacterial activity and cytocompatibility evaluation https://doi.org/10.1007/S12598-021-01852-8/FIGURES/10
  81. Lin et al. (2016) Design and characterization of a novel biocorrodible iron-based drug-eluting coronary scaffold (pp. 72-79) https://doi.org/10.1016/j.matdes.2015.11.045
  82. Liu and Zheng (2011) Effects of alloying elements (Mn Co, Al, W, Sn, B, C and S) on biodegradability and in vitro biocompatibility of pure iron (pp. 1407-1420) https://doi.org/10.1016/J.ACTBIO.2010.11.001
  83. Liu et al. (2011) In vitro investigation of Fe30Mn6Si shape memory alloy as potential biodegradable metallic material (pp. 540-543) https://doi.org/10.1016/j.matlet.2010.10.068
  84. Liu et al. (2020) Microstructure, mechanical properties, degradation behavior, and biocompatibility of porous Fe-Mn alloys fabricated by sponge impregnation and sintering techniques (pp. 485-496) https://doi.org/10.1016/j.actbio.2020.07.048
  85. Loffredo et al. (2018) Iron-based degradable implants (pp. 1-12) Elsevier
  86. Mandal et al. (2019) Fe–Mn–Cu alloy as biodegradable material with enhanced antimicrobial properties (pp. 323-0327) https://doi.org/10.1016/j.matlet.2018.11.117
  87. Mandal et al. (2021) Effects of multiscale porosity and pore interconnectivity on in vitro and in vivo degradation and biocompatibility of Fe–Mn–Cu scaffolds (pp. 4340-4354) https://doi.org/10.1039/D1TB00641J
  88. Md Yusop et al. (2021) Insight into the bioabsorption of Fe-based materials and their current developments in bone applications https://doi.org/10.1002/BIOT.202100255
  89. Montufar et al. (2016) Spark plasma sintering of load-bearing iron-carbon nanotube-tricalcium phosphate cermets for orthopaedic applications (pp. 1134-1142) https://doi.org/10.1007/S11837-015-1806-9/FIGURES/8
  90. Moravej and Mantovani (2011) Biodegradable metals for cardiovascular stent application: Interests and new opportunities (pp. 4250-4270) https://doi.org/10.3390/ijms12074250
  91. Moravej et al. (2010) Electroformed iron as new biomaterial for degradable stents: development process and structure-properties relationship (pp. 1726-1735) https://doi.org/10.1016/j.actbio.2010.01.010
  92. Moravej et al. (2010) Electroformed pure iron as a new biomaterial for degradable stents: in vitro degradation and preliminary cell viability studies (pp. 1843-1851) https://doi.org/10.1016/j.actbio.2010.01.008
  93. Moravej et al. (2011) Effect of electrodeposition current density on the microstructure and the degradation of electroformed iron for degradable stents (pp. 1812-1822) Elsevier B.V
  94. Morgan et al. (2018) Bone mechanical properties in healthy and diseased states https://doi.org/10.1146/ANNUREV-BIOENG-062117-121139
  95. Mostaed et al. (2016) Novel Zn-based alloys for biodegradable stent applications: design, development and in vitro degradation (pp. 581-602) https://doi.org/10.1016/J.JMBBM.2016.03.018
  96. Moszner et al. (2011) Precipitation hardening of biodegradable Fe-Mn-Pd alloys (pp. 981-991) https://doi.org/10.1016/j.actamat.2010.10.025
  97. Mour et al. (2010) Advances in porous biomaterials for dental and orthopaedic applications (pp. 2947-2974) https://doi.org/10.3390/MA3052947
  98. Murr et al. (2010) Next-generation biomedical implants using additive manufacturing of complex, cellular and functional mesh arrays (pp. 1999-2032) https://doi.org/10.1098/rsta.2010.0010
  99. Niinomi (2008) Metallic biomaterials (pp. 105-110) https://doi.org/10.1007/s10047-008-0422-7
  100. Nouri and Wen (2021) Noble metal alloys for load-bearing implant applications https://doi.org/10.1016/B978-0-12-818831-6.00003-3
  101. Nune et al. (2017) Functional response of osteoblasts in functionally gradient titanium alloy mesh arrays processed by 3D additive manufacturing (pp. 78-88) https://doi.org/10.1016/j.colsurfb.2016.09.050
  102. Obayi et al. (2015) Influence of cross-rolling on the micro-texture and biodegradation of pure iron as biodegradable material for medical implants (pp. 68-77) https://doi.org/10.1016/j.actbio.2015.01.024
  103. Oriňáková et al. (2013) Iron based degradable foam structures for potential orthopedic applications (pp. 12451-12465)
  104. Oriňaková et al. (2016) A study of cytocompatibility and degradation of iron-based biodegradable materials (pp. 1060-1070) https://doi.org/10.1177/0885328215615459
  105. Oriňaková et al. (2019) Evaluation of in vitro biocompatibility of open cell iron structures with PEG coating (pp. 515-518) https://doi.org/10.1016/j.apsusc.2019.01.010
  106. Oriňaková et al. (2020) Surface modifications of biodegradable metallic foams for medical applications 10(9) https://doi.org/10.3390/coatings10090819
  107. Papanikolaou and Pantopoulos (2005) Iron metabolism and toxicity (pp. 199-211) https://doi.org/10.1016/j.taap.2004.06.021
  108. Paramitha et al. (2016) Monitoring degradation products and metal ions in vivo (pp. 19-44) Elsevier Ltd
  109. Paul et al. (2022) Cell-material interactions in direct contact culture of endothelial cells on biodegradable iron-based stents fabricated by laser powder bed fusion and impact of ion release (pp. 439-451) https://doi.org/10.1021/acsami.1c21901
  110. Peuster et al. (2001) A novel approach to temporary stenting : degradable cardiovascular stents produced from corrodible metal—results 6–18 months after implantation into New Zealand white rabbits (pp. 563-569) https://doi.org/10.1136/heart.86.5.563
  111. Prasad et al. (2017) Metallic biomaterials: current challenges and opportunities 10(8) https://doi.org/10.3390/MA10080884
  112. Putra et al. (2021) Extrusion-based 3D printed biodegradable porous iron (pp. 741-756) https://doi.org/10.1016/J.ACTBIO.2020.11.022
  113. Qi et al. (2019) Mechanism of acceleration of iron corrosion by a polylactide coating (pp. 202-218) https://doi.org/10.1021/ACSAMI.8B17125/SUPPL_FILE/AM8B17125_SI_001.PDF
  114. Rahim et al. (2020) In vitro degradation and mechanical behaviour of calcium phosphate coated Mg-Ca alloy https://doi.org/10.1080/10667857.2020.1794278
  115. Rahim et al. (2021) Does acid pickling of Mg-Ca alloy enhance biomineralization? (pp. 1028-1038) https://doi.org/10.1016/J.JMA.2020.12.002
  116. Reindl et al. (2014) Degradation behavior of novel Fe/ß-TCP composites produced by powder injection molding for cortical bone replacement (pp. 8234-8243) https://doi.org/10.1007/s10853-014-8532-5
  117. Reith et al. (2015) Metal implant removal: benefits and drawbacks—a patient survey 151(15) (pp. 1-8) https://doi.org/10.1186/S12893-015-0081-6
  118. Ridzwan et al. (2007) Problem of stress shielding and improvement to the hip implant designs: a review (pp. 460-467) https://doi.org/10.3923/JMS.2007.460.467
  119. Saito (2014) Metabolism of iron stores (pp. 235-254)
  120. Scarcello and Lison (2020) Are Fe-based stenting materials biocompatible? A critical review of in vitro and in vivo studies https://doi.org/10.3390/jfb11010002
  121. Schinhammer et al. (2010) Design strategy for biodegradable Fe-based alloys for medical applications (pp. 1705-1713) https://doi.org/10.1016/j.actbio.2009.07.039
  122. Schinhammer et al. (2012) Recrystallization behavior, microstructure evolution and mechanical properties of biodegradable Fe-Mn-C(-Pd) TWIP alloys (pp. 2746-2756) https://doi.org/10.1016/j.actamat.2012.01.041
  123. Schinhammer et al. (2013) Degradation performance of biodegradable FeMnC(Pd) alloys (pp. 1882-1893) https://doi.org/10.1016/j.msec.2012.10.013
  124. Seal et al. (2009) Biodegradable surgical implants based on magnesium alloys—a review of current research https://doi.org/10.1088/1757-899X/4/1/012011
  125. Seiler and Sigel (1988) Marcel Dekker
  126. Sharipova et al. (2018) Mechanical, degradation and drug-release behavior of nano-grained Fe-Ag composites for biomedical applications (pp. 240-249) https://doi.org/10.1016/j.jmbbm.2018.06.037
  127. Shayesteh Moghaddam et al. (2016) Metals for bone implants: safety, design, and efficacy 11(1) (pp. 1-16) https://doi.org/10.1007/S40898-016-0001-2
  128. Sheikh et al. (2015) Biodegradable materials for bone repair and tissue engineering applications (pp. 5744-5794) https://doi.org/10.3390/ma8095273
  129. Shimko et al. (2005) Effect of porosity on the fluid flow characteristics and mechanical properties of tantalum scaffolds (pp. 315-324) https://doi.org/10.1002/JBM.B.30229
  130. Shuai et al. (2019) Biodegradable metallic bone implants (pp. 544-562) https://doi.org/10.1039/C8QM00507A
  131. Shuai et al. (2019) Bioceramic enhances the degradation and bioactivity of iron bone implant https://doi.org/10.1088/2053-1591/ab45b9
  132. Shuai et al. (2019) Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response https://doi.org/10.1088/2053-1591/AB62F5
  133. Sikora-Jasinska et al. (2017) Synthesis, mechanical properties and corrosion behavior of powder metallurgy processed Fe/Mg2Si composites for biodegradable implant applications (pp. 511-521) https://doi.org/10.1016/j.msec.2017.07.049
  134. Sikora-Jasinska et al. (2019) Understanding the effect of the reinforcement addition on corrosion behavior of Fe/Mg2Si composites for biodegradable implant applications (pp. 771-778) https://doi.org/10.1016/j.matchemphys.2018.11.068
  135. Sing et al. (2015) Degradation behavior of biodegradable Fe35Mn alloy stents (pp. 572-577) https://doi.org/10.1002/JBM.B.33242
  136. Sobral et al. (2011) Three-dimensional plotted scaffolds with controlled pore size gradients: effect of scaffold geometry on mechanical performance and cell seeding efficiency (pp. 1009-1018) https://doi.org/10.1016/j.actbio.2010.11.003
  137. Sun et al. (2021) Laser-modified Fe–30Mn surfaces with promoted biodegradability and biocompatibility toward biological applications (pp. 13772-13784) https://doi.org/10.1007/S10853-021-06139-Y/FIGURES/9
  138. Traverson et al. (2018) In vivo evaluation of biodegradability and biocompatibility of Fe30Mn alloy (pp. 10-16) https://doi.org/10.3415/VCOT-17-06-0080
  139. Trincă et al. (2021) Evaluation of in vitro corrosion resistance and in vivo osseointegration properties of a FeMnSiCa alloy as potential degradable implant biomaterial https://doi.org/10.1016/j.msec.2020.111436
  140. Trumbo et al. (2001) Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc (pp. 294-301) https://doi.org/10.1016/S0002-8223(01)00078-5
  141. Ulum et al. (2014) In vitro and in vivo degradation evaluation of novel iron-bioceramic composites for bone implant applications (pp. 336-344) https://doi.org/10.1016/j.msec.2013.12.022
  142. Ulum et al. (2015) Evidences of in vivo bioactivity of Fe-bioceramic composites for temporary bone implants (pp. 1354-1365) https://doi.org/10.1002/jbm.b.33315
  143. Vojtěch et al. (2011) Mechanical and corrosion properties of newly developed biodegradable Zn-based alloys for bone fixation (pp. 3515-3522) https://doi.org/10.1016/J.ACTBIO.2011.05.008
  144. Waizy et al. (2013) Biodegradable magnesium implants for orthopedic applications (pp. 39-50) https://doi.org/10.1007/s10853-012-6572-2
  145. Wang et al. (2017) In vitro corrosion properties and cytocompatibility of Fe-Ga alloys as potential biodegradable metallic materials (pp. 60-66) https://doi.org/10.1016/j.msec.2016.09.086
  146. Wang et al. (2017) In vitro degradation and surface bioactivity of iron-matrix composites containing silicate-based bioceramic (pp. 10-18) https://doi.org/10.1016/j.bioactmat.2016.12.001
  147. Wegener et al. (2011) Microstructure, cytotoxicity and corrosion of powder-metallurgical iron alloys for biodegradable bone replacement materials (pp. 1789-1796) Elsevier B.V
  148. Wegener et al. (2020) Development of a novel biodegradable porous iron-based implant for bone replacement (pp. 1-10) https://doi.org/10.1038/s41598-020-66289-y
  149. Wegener et al. (2021) Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model 111(11) (pp. 1-11) https://doi.org/10.1038/s41598-021-91296-y
  150. Wen et al. (2013) A construction of novel iron-foam-based calcium phosphate/chitosan coating biodegradable scaffold material (pp. 1022-1031) https://doi.org/10.1016/j.msec.2012.10.009
  151. Wong et al. (2012) CRC https://doi.org/10.1201/b13687
  152. Xu et al. (2015) Microstructure and degradation behavior of forged Fe–Mn–Si alloys https://doi.org/10.1142/S0217979215400147
  153. Xu et al. (2015) A comparative study of powder metallurgical (PM) and wrought Fe-Mn-Si alloys (pp. 116-124) https://doi.org/10.1016/j.msea.2015.02.021
  154. Yang et al. (2018) 3D printed Fe scaffolds with HA nanocoating for bone regeneration (pp. 608-616) https://doi.org/10.1021/acsbiomaterials.7b00885
  155. Yang et al. (2020) Mg bone implant: features, developments and perspectives https://doi.org/10.1016/J.MATDES.2019.108259
  156. Yusop et al. (2015) Controlling the degradation kinetics of porous iron by poly(lactic-co-glycolic acid) infiltration for use as temporary medical implants https://doi.org/10.1038/srep11194
  157. Zadpoor and Malda (2017) Additive manufacturing of biomaterials, tissues, and organs (pp. 1-11) https://doi.org/10.1007/s10439-016-1719-y
  158. Zberg et al. (2009) MgZnCa glasses without clinically observable hydrogen evolution for biodegradable implants 811(8) (pp. 887-891) https://doi.org/10.1038/nmat2542
  159. Zhang and Cao (2015) Degradable porous Fe-35wt.%Mn produced via powder sintering from NH4HCO3 porogen (pp. 394-401) https://doi.org/10.1016/j.matchemphys.2015.07.056
  160. Zhang et al. (2010) Biocorrosion properties and blood and cell compatibility of pure iron as a biodegradable biomaterial (pp. 2151-2163) https://doi.org/10.1007/s10856-010-4070-0
  161. Zhao et al. (2020) Study on Fe-xGO composites prepared by selective laser melting: microstructure, hardness, biodegradation and cytocompatibility (pp. 1163-1174) https://doi.org/10.1007/s11837-019-03814-z
  162. Zheng et al. (2014) Biodegradable metals (pp. 1-34) https://doi.org/10.1016/j.mser.2014.01.001
  163. Zheng Y, Xu X, Xu Z, Wang J, Cai H (2017) Development of Fe-based degradable metallic biomaterials. In: Metallic biomaterials. Wiley, Oxford, pp 113–160.
  164. https://doi.org/10.1002/9783527342440.ch4
  165. Zhu et al. (2009) Corrosion resistance and blood compatibility of lanthanum ion implanted pure iron by MEVVA (pp. 99-104) https://doi.org/10.1016/j.apsusc.2009.07.082
  166. Zhu et al. (2009) Biocompatibility of pure iron: In vitro assessment of degradation kinetics and cytotoxicity on endothelial cells (pp. 1589-1592) https://doi.org/10.1016/J.MSEC.2008.12.019