10.1007/s40204-021-00173-4

Fabrication of porous TiO2 foams by powder metallurgy technique and study of bulk crushing strength for biomedical application

  • Farida Ahmed Koly1,
  • Md. Arafat Rahman*1,
  • Md. Saiful Islam2,
  • Md. Mizanur Rahman1,
  1. Department of Mechanical Engineering, Chittagong University of Engineering and Technology, Chittagong, 4349, BD
  2. Department of Glass and Ceramic Engineering, Bangladesh University of Engineering and Technology, Dhaka, BD

Published in Issue 2021-11-16

How to Cite

Koly, F. A., Rahman, M. A., Islam, M. S., & Rahman, M. M. (2021). Fabrication of porous TiO2 foams by powder metallurgy technique and study of bulk crushing strength for biomedical application. Progress in Biomaterials, 10(4 (December 2021). https://doi.org/10.1007/s40204-021-00173-4
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Abstract

Abstract Despite the importance of porous titanium oxide (PA-TiO 2 ) in diverse functional applications, very little information is available on the compatible mechanical properties for potential biomedical applications. In this study, PA-TiO 2 foam was synthesized using space-holding powder metallurgy and sintering methods to produce interconnected opened-cell structure with surface morphology of mountain-like features associated with the extensive rift valley system. Three different types of PA-TiO 2 foams with porosities of 35–52% and mean pore diameter of 190–210 μm were fabricated for evaluating the effect of porosity on mechanical properties of bulk PA-TiO 2 . The modulus of elasticity of PA-TiO 2 foams exhibited in the range of 45–262 MPa which was within the range of modulus of elasticity of human cancellous bone. Cytotoxicity test is performed in vitro analysis to observe the effect of cell toxicity to produce osteointegration when used as implantable materials. There was no cytotoxicity effect found and remarkable cell growth was observed for human cancerous (HeLa) cell line. However, there was no cytotoxicity effect found and cell growth was not observed for Vero cell line. This study suggested that PA-TiO 2 facilitates cell growth without spreading toxicity and has mechanical properties of cancellous bone. Hence, it has potential application as implant and medical devices in biomedical applications.

Keywords

  • Mechanical property,
  • Porous,
  • TiO2,
  • Cytotoxicity,
  • HeLa cell,
  • Vero Cell

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