10.1007/s40204-021-00161-8

Magnetic dual-responsive semi-IPN nanogels based on chitosan/PNVCL and study on BSA release behavior

  • Hamed Mohammad Gholiha1,
  • Morteza Ehsani*2,
  • Ardeshir Saeidi1,
  • Azam Ghadami3,
  • Najmeh Alizadeh1,
  1. Department of Polymer Engineering, Science and Research Branch, Islamic Azad University, Tehran, IR
  2. Department of polymer processing, Iran polymer and petrochemical institute (IPPI), Tehran, IR Department of Polymer Engineering, Faculty of Engineering, South Tehran Branch, Islamic Azad University, Tehran, IR
  3. Department of Chemical and Polymer Engineering, Central Tehran Branch, Islamic Azad University, Tehran, IR

Published in Issue 2021-08-09

How to Cite

Mohammad Gholiha, H., Ehsani, M., Saeidi, A., Ghadami, A., & Alizadeh, . N. (2021). Magnetic dual-responsive semi-IPN nanogels based on chitosan/PNVCL and study on BSA release behavior. Progress in Biomaterials, 10(3 (September 2021). https://doi.org/10.1007/s40204-021-00161-8
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Abstract

Abstract Magnetic thermoresponsive nanogels present a promising new approach for targeted drug delivery. In the present study, bovine serum albumin (BSA) loaded thermo-responsive magnetic semi-IPN nanogels (MTRSI-NGs) were developed. At first poly( N -vinyl caprolactam) (PNVCL) was synthesized by free radical polymerization and then MTRSI-NGs were prepared by crosslinking chitosan in presence of chitosan and Fe 3 O 4 . The formation of MTRSI-NGs has been confirmed by FTIR, and the average molecular weight of PNVCL was determined by GPC analysis. Rheological and turbidimetry analysis were used to determine lower critical solution temperature (LCST) of PNVCL and magnetic thermo-responsive nanogels (MTRSI-NGs) around 32 and 37 °C, respectively. FE-SEM analysis showed particle size at less than 20 nm in the dried state. Dynamic light scattering determined particle size at about 30 nm in a swelling state. The analysis of release behavior showed that the BSA release ratio at 40 °C was faster than 25 °C. The pH release behavior was evaluated at pH 5.5 and 7.4 and showed that the drug release rate at pH 5.5 was more rapid than pH 7.4. The results show MTRSI-NGs are applicable to protein targeted delivery by thermosensitive targeted drug delivery systems.

Keywords

  • Magnetic thermoresponsive nanogels,
  • Poly(N-vinyl caprolactam),
  • Chitosan nanogel,
  • Albumin release behavior,
  • Target drug delivery,
  • Semi-IPN nanogels

References

  1. Abedini et al. (2018) Overview on natural hydrophilic polysaccharide polymers in drug delivery 29(10) (pp. 2564-2573) https://doi.org/10.1002/pat.4375
  2. Aguilar et al. (2019) Introduction to smart polymers and their applications (pp. 1-11) Woodhead Publishing
  3. Alibolandi et al. (2016) Folate receptor-targeted multimodal polymersomes for delivery of quantum dots and doxorubicin to breast adenocarcinoma: in vitro and in vivo evaluation 500(1–2) (pp. 162-178) https://doi.org/10.1016/j.ijpharm.2016.01.040
  4. Banihashem et al. (2020) Synthesis of chitosan-grafted-poly (N-vinylcaprolactam) coated on the thiolated gold nanoparticles surface for controlled release of cisplatin https://doi.org/10.1016/j.carbpol.2019.115333
  5. Bouillot and Vincent (2000) A comparison of the swelling behaviour of copolymer and interpenetrating network microgel particles 278(1) (pp. 74-79) https://doi.org/10.1007/s003960050012
  6. Butler and Gilson (2014) A theoretical investigation of the products in the Frankland reaction of dimethylzinc compounds with nitric oxide 92(10) (pp. 948-950) https://doi.org/10.1139/cjc-2014-0049
  7. Cheng et al. (2013) Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery 34(14) (pp. 3647-3657) https://doi.org/10.1016/j.biomaterials.2013.01.084
  8. Cheng et al. (2015) Characterization of novel composite alginate chitosan–carrageenan nanoparticles for encapsulation of BSA as a model drug delivery system 12(3) (pp. 351-357) https://doi.org/10.2174/1567201812666150114155948
  9. Dinari et al. (2021) Design and fabrication of dual responsive lignin- based nanogel via “grafting from” atom transfer radical polymerization for curcumin loading and release 11(1) (pp. 1-16) https://doi.org/10.1038/s41598-021-81393-3
  10. Elzoghby et al. (2012) Albumin-based nanoparticles as potential controlled release drug delivery systems 157(2) (pp. 168-182) https://doi.org/10.1016/j.jconrel.2011.07.031
  11. Fernández-Quiroz et al. (2015) Effect of the molecular architecture on the thermosensitive properties of chitosan-g-poly (N-vinylcaprolactam) (pp. 92-101) https://doi.org/10.1016/j.carbpol.2015.07.069
  12. Gislén et al. (2003) Superior underwater vision in a human population of sea gypsies 13(10) (pp. 833-836) https://doi.org/10.1016/S0960-9822(03)00290-2
  13. He et al. (2013) Magnetic nanoparticles for imaging technology 10(10–11) (pp. 930-944) https://doi.org/10.1504/IJNT.2013.058120
  14. Huang et al. (2017) Micellization and gelatinization in aqueous media of pH-and thermo-responsive amphiphilic ABC (PMMA 82-b-PDMAEMA 150-b-PNIPAM 65) triblock copolymer synthesized by consecutive RAFT polymerization 7(46) (pp. 28711-28722) https://doi.org/10.1039/C7RA04351A
  15. Karimzadeh et al. (2017) Effective preparation, characterization and in situ surface coating of super paramagnetic Fe3O4 nanoparticles with polyethyleneimine through cathodic electrochemical deposition (CED) 13(2) (pp. 167-174) https://doi.org/10.2174/1573413713666161129160640
  16. Kozanoǧlu et al. (2011) Polymerization of N-vinylcaprolactam and characterization of poly (N-vinylcaprolactam) 48(6) (pp. 467-477) https://doi.org/10.1080/10601325.2011.573350
  17. Lee et al. (2013) Initiated chemical vapor deposition of thermoresponsive poly (N-vinylcaprolactam) thin films for cell sheet engineering 9(8) (pp. 7691-7698) https://doi.org/10.1016/j.actbio.2013.04.049
  18. Namdeo et al. (2008) Magnetic nanoparticles for drug delivery applications 8(7) (pp. 3247-3271) https://doi.org/10.1166/jnn.2008.399
  19. Owens et al. (2007) Thermally responsive swelling properties of polyacrylamide/poly (acrylic acid) interpenetrating polymer network nanoparticles 40(20) (pp. 7306-7310) https://doi.org/10.1021/ma071089x
  20. Patel et al. (2010) Chitosan mediated targeted drug delivery system: a review 13(4) (pp. 536-557) https://doi.org/10.18433/J3JC7C
  21. Rao et al. (2016) Stimuli responsive poly (N-vinylcaprolactam) gels for biomedical applications 2(1) https://doi.org/10.3390/gels2010006
  22. Rinaudo (2006) Chitin and chitosan: properties and applications 31(7) (pp. 603-632) https://doi.org/10.1016/j.progpolymsci.2006.06.001
  23. Sadighian et al. (2015) pH-Triggered magnetic-chitosan nanogels (MCNs) for doxorubicin delivery: physically vs. chemically cross-linking approach 5(1) https://doi.org/10.5681/apb.2015.016
  24. Sahu et al. (2011) Hydrophobically modified carboxymethyl chitosan nanoparticles targeted delivery of paclitaxel 19(2) (pp. 104-113) https://doi.org/10.3109/10611861003733987
  25. Sarkar et al. (2005) An effective method for preparing polymer nanocapsules with hydrophobic acrylic shell and hydrophilic interior by inverse emulsion radical polymerization 38(20) (pp. 8603-8605) https://doi.org/10.1021/ma050661m
  26. Schmidt (2007) Thermoresponsive magnetic colloids 285(9) (pp. 953-966) https://doi.org/10.1007/s00396-007-1667-z
  27. Siirilä et al. (2019) Soft poly (N- vinylcaprolactam) nanogels surface-decorated with AuNPs. Response to temperature, light, and RF-field (pp. 59-69) https://doi.org/10.1016/j.eurpolymj.2019.03.010
  28. Smith et al. (2021) Controlling properties of thermogels by tuning critical solution behaviour of ternary copolymers 12(13) (pp. 1918-1923) https://doi.org/10.1039/D0PY01696A
  29. Ta and Pulat (2012) 5-fluorouracil encapsulated chitosan nanoparticles for pH-stimulated drug delivery: evaluation of controlled release kinetics https://doi.org/10.1155/2012/313961
  30. Tong and Anderson (1996) Partitioning and diffusion of proteins and linear polymers in polyacrylamide gels 70(3) (pp. 1505-1513) https://doi.org/10.1016/S0006-3495(96)79712-6
  31. Uhrich et al. (1999) Polymeric systems for controlled drug release 99(11) (pp. 3181-3198) https://doi.org/10.1021/cr940351u
  32. Vihola et al. (2005) Cytotoxicity of thermosensitive polymers poly (N-isopropylacrylamide), poly (N-vinylcaprolactam) and amphiphilically modified poly (N-vinylcaprolactam) 26(16) (pp. 3055-3064) https://doi.org/10.1016/j.biomaterials.2004.09.008
  33. Wang et al. (2014) Stimuli-responsive materials for controlled release of theranostic agents 24(27) (pp. 4206-4220) https://doi.org/10.1002/adfm.201400279
  34. Ward and Georgiou (2011) Thermoresponsive polymers for biomedical applications 3(3) (pp. 1215-1242) https://doi.org/10.3390/polym3031215
  35. Weber et al. (2012) Temperature responsive bio-compatible polymers based on poly (ethylene oxide) and poly (2-oxazoline) s 37(5) (pp. 686-714) https://doi.org/10.1016/j.progpolymsci.2011.10.002
  36. Yadav et al. (2019) Natural polysaccharides: structural features and properties (pp. 1-17) Woodhead Publishing
  37. Zhao et al. (2009) Preparation and inductive heating property of Fe3O4–chitosan composite nanoparticles in an AC magnetic field for localized hyperthermia 477(1–2) (pp. 739-743) https://doi.org/10.1016/j.jallcom.2008.10.104
  38. Zhuang et al. (2013) Multi-stimuli responsive macromolecules and their assemblies 42(17) (pp. 7421-7435) https://doi.org/10.1039/C3CS60094G
  39. Zuo et al. (2017) Chitosan based nanogels stepwise response to intracellular delivery kinetics for enhanced delivery of doxorubicin (pp. 157-164) https://doi.org/10.1016/j.ijbiomac.2017.06.020