10.1007/s40204-021-00155-6

Injectable hyaluronic acid-based antibacterial hydrogel adorned with biogenically synthesized AgNPs-decorated multi-walled carbon nanotubes

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  • Pooyan Makvandi1,
  • Milad Ashrafizadeh2,
  • Matineh Ghomi3,
  • Masoud Najafi*4,
  • Hamid Heydari Sheikh Hossein5,
  • Ali Zarrabi6,
  • Virgilio Mattoli1,
  • Rajender S. Varma7,
  1. Istituto Italiano di Tecnologia, Centre for Materials Interface, Pontedera, Pisa, 56025, IT
  2. Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, 51666-16471, IR Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul, 34956, TR
  3. Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, 61537-53843, IR
  4. Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, 6715847141, IR Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, IR
  5. Department of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, IR
  6. Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul, 34956, TR
  7. Regional Centre of Advanced Technologies and Materials, Palacky University, Olomouc, 783 71, CZ
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Published in Issue 2021-03-26

Copyright (c) -1 Copyright © 2024, The Author(s), under exclusive licence to Islamic Azad University

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Makvandi, P., Ashrafizadeh, M., Ghomi, M., Najafi, M., Hossein, H. H. S., Zarrabi, A., Mattoli, V., & Varma, R. S. (2021). Injectable hyaluronic acid-based antibacterial hydrogel adorned with biogenically synthesized AgNPs-decorated multi-walled carbon nanotubes. Progress in Biomaterials, 10(1 (March 2021). https://doi.org/10.1007/s40204-021-00155-6
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Abstract

Abstract Injectable materials have shown great potential in tissue engineering applications. However, bacterial infection is one of the main challenges in using these materials in the field of regenerative medicine. In this study, biogenically synthesized silver nanoparticle-decorated multi-walled carbon nanotubes (Ag/MWCNTs) were deployed for adorning biogenic-derived AgNPs which were subsequently used in the preparation of thermosensitive hydrogels based on hyaluronic acid encompassing these green-synthesized NPs. The antibacterial capacity of AgNPs decorated on MWCNTs synthesized through Camellia sinensis extract in an organic solvent-free medium displayed a superior activity by inhibiting the growth of Gram-negative ( E. coli and Klebsiella) and Gram-positive ( S. aureus and E. faecalis ). The injectable hydrogel nanocomposites demonstrated good mechanical properties, as well. The thermosensitive hyaluronic acid-based hydrogels also exhibited T gel below the body temperature, indicating the transition from liquid-like behavior to elastic gel-like behavior. Such a promising injectable nanocomposite could be applied as liquid, pomade, or ointment to enter wound cavities or bone defects and subsequently its transition in situ to gel form at human body temperature bodes well for their immense potential application in the biomedical sector.

Keywords

  • Ag NPs,
  • Green synthesis,
  • Camellia sinensis,
  • Antibacterial,
  • Nanomedicine,
  • Injectable nanocomposite,
  • Thermosensitive hydrogels
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