Inhibition breast cancer by (Cu-Se) nanoparticles generated by plasma jet

Authors

• Doaa Rifaat Jassim ¹
• Ban H. Adil * ¹
• Ramiz Ahmed Al-ansari ¹

• Department of Physics, College of Science for Women,,University of Baghdad, Baghdad, Iraq

Abstract

This work discusses the synthesis of (Cu-Se) core-shell nanoparticles using a plasma jet, using aqueous solutions of copper and selenium salts as a precursor. The structural properties of the resultant (Cu-Se) core-shell nanostructures were examined using UV, XRD, and SEM. The diameter of the granules with a concentration of 3:7 is 17 nm. Thus, utilising the designated diameter.
Next, a comparison was made between the MDA cell line—which had been treated to Cu-Se NPs as an anti-cancer (breast cancer) agent—and the normal cell line REF. For every set, the following parameter was evaluated: (i) the proportion of breast cancer cells whose proliferation was inhibited after exposure for (24, 48) hours; (ii) the cytotoxicity of normal cells after (24, 48) hours. We diluted the nanomaterial five times and found that the cytotoxicity in normal cells does not exceed 22%, indicating that its effect is not detrimental to normal cells. Meanwhile, the nanomaterial’s effects were observed on cancer cells after 24 hours, at roughly 63%, and after 48 hours, at roughly 93%, and the census was carried out with these cells.

Keywords

• Plasma jet
• (Cu-Se) NPs
• MDA cells line
• REF cells line
• Growth inhibition
• Cytotoxicity