10.1186/2193-8865-3-18

Size-dependent in vivo/in vitro results of homoeopathic herbal extracts

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  • Rajesh Barve1,
  • Ramesh Chaughule*2,
  1. Department of Repertory, Virar Homoeopathic Medical College, Virar, Maharashtra, 401305, IN
  2. Department of Chemistry, Ramnarain Ruia College, Matunga, Mumbai, 400019, IN
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Published in Issue 23-04-2013

How to Cite

Barve, R., & Chaughule, R. (2013). Size-dependent in vivo/in vitro results of homoeopathic herbal extracts. Journal of Nanostructure in Chemistry, 3(1 (December 2013). https://doi.org/10.1186/2193-8865-3-18
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Abstract

Abstract This paper presents evidence-based results of clinical trial on the use of nanosized particles in homoeopathic Terminalia arjuna tincture. Dynamic light scattering technique demonstrates that homoeopathic tincture is a mixture of particles varying from micron to nanometre sizes. The process of succussion, homogenization and filtration brings down the particles of source material to nanosize as a ‘top-down’ process. As compared to the conventionally used micron-sized T. arjuna powder, the results show significant clinical improvement due to the presence of nanoparticles in tincture by the above method. Similar results were reconfirmed on experiments with bacterial cultures. From clinical trials, it has been confirmed that the dose of medicine required by the patient is significantly reduced with the reduction in particle size. No toxicity was observed even after giving medicine for more than 8 weeks. Size-dependent sensitivity of the drug can help to tackle the problem of drug resistance in bacteria.

Keywords

  • Lipid profile,
  • Terminalia arjuna,
  • Homoeopathy,
  • Clinical trials,
  • DLS method,
  • Holarrhena antidysenterica,
  • E. coli cultures,
  • Zone of inhibition
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References

  1. Kumar et al. (2007) Steroidal alkaloids from Holarrhena antidysenterica (L.) Wall 55(6) https://doi.org/10.1248/cpb.55.912
  2. Singh (1986) Clinical studies of amoebiasis and giardiasis evaluating the efficacy of kutaja (Holarrhena autidysenterica) in Eutamoeta histotylica cyst passes (pp. 228-231)
  3. Warrier et al. (1996) Orient Blackswan
  4. Sharma et al. (1982) Arjunolone – a new flavone from stem bark of Terminalia arjuna
  5. Nema et al. (2012) Preliminary phytochemical evaluation and flavonoids quantification of Terminalia arjuna leaves extract 1(5)
  6. Nema et al. (2012) Antibacterial and antifungal activity of Terminalia arjuna leaves extract with special reference to flavonoids 1(5)