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Keyword: Thiourea

Original Article
Facile synthesis of dihydropyrimidinone derivatives via Biginelli reaction using Brønsted acidic ionic liquid [H-NMP]+[CH3SO3]- as an efficient homogeneous catalyst

In this research, a green, operationally simple, highly efficient and facile cascade Biginelli reaction using various aromatic aldehydes, ethyl acetoacetate, and urea/thiourea has been developed. First, the ionic liquid was prepared from the reaction of 1-methyl-2-pyrolidone with methane sulfonic acid. Then, this ionic liquid was applied as an acidic catalyst in the synthesis of dihydropyrimidinones […]