An efficient green route for the preparation of naphthoxazinones, applying a three-component one-pot condensation reaction of 2-naphthol, aromatic aldehyde and urea in the presence of nano silica supported ferric chloride under solvent-free conditions has been developed. The present procedure offers several advantages such as short reaction time, simple workup, recovery and reusability of the catalyst.
ZrP2O7 nanoparticles (NPs) as an efficient catalyst have been used for the preparation of 1,6-diamino-2- oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile derivatives via one-pot coupling of hyrazine hydrate, ethyl cyanoacetate, malononitrile and aromatic aldehydes under reflux conditions in ethanol. Using this method we obtained low reaction times, easy isolation of the targeted molecules, excellent yields.
A simple, mild and high efficient procedure for one pot three component synthesis of 2-amino 4-H chromene derivatives was studied. The reaction was performed in water using aryl aldehydes, malononitrile and resorcinol, phloroglucinol or naphthole in the presence of N-methyl D-glucamine (Meglumine) as a green high efficient catalyst. The reaction was studied in thermal, microwave […]
An atom-efficient, eco-friendly, solvent-free, high yielding, multicomponent green strategy to synthesize triazolo[1,2-a]indazole-triones derivatives by the one-pot condensation of aldehyde, dimedone, and phenyl urazole is presented. A series of different substituted aromatic aldehydes including either electron-withdrawing or electron-donating groups used in this reaction participated well and gave the corresponding products in good to excellent yield. Poly […]
This study introduces a green and efficient method for preparation of biologically-active substituted 4H-pyrans using the one-pot three-component reaction of aromatic aldehydes, dimedone and malononitrile in the presence of cobalt oxide nanoparticles. Co3O4 nanoparticles were used as an efficient catalyst for the synthesis of polyhydroquinoline derivatives by the reaction of aromatic aldehydes, ethyl acetoacetate, dimedone […]
The preparation of trans-dihydrofurans has been achieved by a one-pot condensation reaction of 4-bromophenacyl bromide, aromatic aldehydes and 5,5-dimethyl-1,3-cyclohexanedione using biosynthesized CuO nanoparticles under reflux conditions in ethanol. CuO nanoparticles (CuO NPs) were prepared using extractof leaves of Ajuga chamaecistus Subsp. Scoparia. The key advantages of this process are the diastereoselective synthesis, reusability of the […]
Mesoporous CoAl2O4 spinel nanocrystals ( nano-CoAl2O4 ) were synthesized and fully characterized by X- ray diffraction patterns (XRD), energy-dispersive X-ray spectroscopy (EDS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), DLS (dynamic light scattering) and FT-IR. The nanocrystals promoted the preparation of quinazolinones via the one-pot, three component condensation reaction of benzaldehydes, isatoic anhydride, primary […]
In this study, two different methods were described for the synthesis of 2-(aryl)-3-((2-oxo-2-(2-oxo-2H-chromen-3-yl)ethyl)amino)imidazolidin-4-one derivatives under microwave irradiation. The first method was step by step method. In step by step method, 3-(2-hydrazinylacetyl)-2H-chromen-2-one and aromatic aldehydes in 1 mL of absolute ethanol were irradiated with appropriate power within 3-10 min to obtain imine products. Then, the imine […]
Densely functionalized 3,4-dihydropyridones were synthesized by a four-component reaction of Meldrumʼs acid, ethyl acetoacetate, ammonium acetate, and proper aromatic aldehydes in the presence of novel organic-inorganic cobalt incorporated magnetic nanocatalyst (γ-Fe2O3@HAp/Co(II)) using ethanol as a green solvent at reflux condition. This new synthetic method provided the target compounds in a high yield (70-95%) and lower […]
Lanthanum (III) oxide (La2O3) was applied as an efficient bifunctional catalyst to develop a new methodology in the production of 2-amino-4-aryl-4H-pyrans and pyrazolopyranopyrimidines in the absence of solvent. In both synthetic protocol, due to the dual functionality of lanthanum (III) oxide (i.e. having basic and acidic Lewis sites), it was very useful and general, and […]
