An efficient synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles by one-step condensation of an aldehyde, benzil, ammonium acetate and primary amine in the presence of nanocrystalline magnesium aluminate under microwave irradiation is described. The advantages of this catalyst are including simple work-up, low cost and reusability. Compared with conventional methods, the main advantages of the present […]
In the present work, we have developed a mild, efficient, and environmentally benign method for the synthesis of tetrahydrobenzo[b]pyran derivatives via a three-component cyclocondensation of aldehydes, malononitrile and dimedone utilizing ammonium chloride as a simple, easily available and cost effective catalyst under microwave irradiation. This method has several attracting features such as simple experimental set […]