Vitamin B12 used as effective biocatalyst for the synthesis of pyrano[2,3-c]cromenes and pyrano[2,3-d]pyrimidines

Authors

• Ghasem Marandi * ¹
• Reyhaneh Nadernia ²
• Nourallah Hazeri ²
• Malek Taher Maghsoodlou ²

1. Organic Chemistry Department, Faculty of Chemistry, Urmia University, Urmia, Iran
2. Chemistry Department, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

Abstract

Synthesis of organic compounds using some natural compounds as catalysts has gained more attention in recent decades. With respect to the importance of these procedures, the synthesis of 3,4-dihydropyrano[2,3-c]chromene and pyrano[2,3-d]pyrimidine derivatives using vitamin B₁₂ by a one-pot reaction of malononitrile, benzaldehydes and 4-hydroxycumarine or 1,3-dimethylbarbituric acid is reported.

Graphical Abstract

Keywords

• Vitamin B12
• Aldehydes
• Pyrano[2
• 3-c]chromene
• 3-d]pyrimidine
• Biocatalyst. Green route