Synthesis of 1,3,5-tri-substituted pyrazoles promoted by P2O5.SiO2

Authors

• Abdolhamid Bamoniri ¹
• BiBi Fatemeh Mirjalili ²
• Abbas Ali Jafari ³
• Fatemeh Abasaltian ³

1. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran
2. Department of Chemistry, College of Science, Yazd University, P. O. Box 89195-741, Yazd. Iran.
3. Department of Chemistry, College of Science, Yazd University, P.O.Box 89195-741, Yazd, I.R.Iran.

Abstract

Silica supported phosphorus pentoxide (P₂O₅·SiO₂) is an efficient catalyst for synthesis of 1,3,5-substituted pyrazoles via the condensation of 1,3-diketones and hydrazines. Simplicity of procedure, mild condition, being solvent-free, high yields, and easy workup are some advantages of this protocol.

Keywords

• Solvent-free
• P2O5.SiO2
• 5-tri-substituted pyrazoles
• 3-diketones. Hydrazines