Synthesis and in vitro antibacterial study of dihydropyrano[3,2-c]chromene derivatives by nano fluoro apatite doped with Mg and Si as a cooperative catalyst

Authors

• Elmira Jahangard ¹
• Leila Khazdooz * ^{1, 2}
• Amin Zarei ³

1. Department of Science, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan 81595-158, Iran
2. Laser and Biophotonics in Biotechnologies Research Center, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan 81595-158, Iran
3. Department of Science, Fasa Branch, Islamic Azad University, PO Box No. 364, Fasa 7461713591, Fars, Iran.

Abstract

One of the important Multi-component reaction (MCRs) is the synthesis of dihydropyrano chromene derivatives by one-pot reaction. In this research, an inexpensive and effective one pot three component procedure with good yields for the synthesis of dihydro pyrano chromenes is reported. In this method, the synthesis of pyrano chromene derivatives was followed by using 4-hydroxycoumarin, malononitrile and aldehydes in the presence of catalytic amount of nano fluoro apatite doped with Mg and Si (Mg-Si-FA). It should be cited that all reactions were carried out in H₂O/EtOH as the solvent under reflux condition and the corresponding products were obtained in good yields and pretty short reaction time. Moreover, the anti-bacterial properties of the present products were studied by determination of their minimum inhibitory concentration (MIC).

Keywords

• Dihydropyrano[3
• 2-c]chromene
• Cooperative catalyst
• Multi-component reaction
• Antibacterial activity