Suzuki-Miyaura cross-coupling reaction catalyzed using highly efficient CN-dimeric ortho-palladated complex under microwave irradiation and conventional heating

Authors

• Abdol Reza Hajipour ¹
• Fatemeh Abrishami ²
• Fatemeh Rafiee ³

1. Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, Islamic Republic of Iran
2. Department of Chemistry and Chemical Engineering, Malek-Ashtar University of Technology, Tehran, Iran.
3. Department of Organic Chemistry, Faculty of Chemistry, Alzahra University, Tehran, Iran

Abstract

Suzuki cross-coupling reaction of different aryl halides with arylboronic acids was successfully carried out in methanol using ortho-palladated complex of 2-methoxyphenethylamine. All substrates afforded the corresponding products in good to high yields in the presence of low amounts of this complex as efficient and active catalyst. Application of microwave irradiation improved the yields of the reactions and reduced the reaction times some extent in comparison with traditional heating conditions.

Keywords

• Arylboronic acid.
• Ortho-palladated complex
• Suzuki–Miyaura reaction
• Aryl halide
• 2-Methoxyphenethylamine