Preparation of Fe3O4@APTES-TA-MA covalent organic framework nanocatalyst for the construction of N-amino-2-pyridone analogs

Authors

• Amaeneh Mosaffaeirad ¹
• Masoud Mokhtary * ¹
• Mohammad Nikpassand ¹

• Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran

Abstract

In this work, an efficient method for the construction of N-amino-2-pyridone analogs was performed using the condensation of aldehyde, malononitrile and cyanoacetohydrazide through Fe3O4@aminopropyltriethoxysilane-terephthaldehyde-melamine (Fe3O4@APTES-TA-MA) as an efficient recyclable magnetic covalent organic framework nanocatalyst in ethanol at reflux conditions. Fe3O4@APTES-TA-MA was characterized via FT-IR, EDS, SEM, TEM, VSM, and TGA methods. The average size of the nanoparticles was found between 40−90 nm. Clean procedure, short reaction time, and high efficiency are some benefits of this protocol. Also, the nanomagnetic catalyst can be reused five times without significant loss of its activity.

Highlights:

·      A series of N–amino-2-pyridone analogs were synthesized

·  Fe₃O₄@APTES-TA-MA covalent organic framework prepared and characterized by different spectroscopic techniques.

·       High yields and easy work-up procedure are some advantages of this protocol.

·      The catalyst is easily recycled by magnetic attraction.

Graphical Abstract

Keywords

• Magnetic catalyst
• Covalent Organic Frameworks
• One-pot reaction.
• Cyanoacetohydrazide
• N-Amino-2-pyridone