One-pot synthesis of tri- and tetrasubstituted imidazoles using nano-LaMnO3 perovskite-type oxide as reusable heterogeneous catalyst in solvent-free condition

Authors

• Haleh Sanaeishoar ¹
• Haman Tavakkoli ¹
• Mahsa Asareh ²
• Fouad Mohave ³

1. Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.
2. Department of Chemistry, Dezful Branch, Islamic Azad University, Dezful, Iran.
3. Young Researchers and Elite Club, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.

Abstract

A convenient synthetic method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazole derivatives, has been developed via one-pot condensation reaction in solvent-free condition when aldehyde, ammonium acetate/amine, and 1,2-diketone are reacted using 0.8 mol% of NP-LaMnO3 at 80 °C under solvent free conditions. Catalyst could be recovered and reused in five reaction cycles without any loss of its activities, giving a total turnover number (TON) = 594 and turn over frequency (TOF) = 71 h−1. High yield, little catalyst loading, elimination of solvent, simple workup, recovery and reusability of the catalyst are some of the impressive features of the present method.

Keywords

• imidazole
• One-pot synthesis
• Perovskite-type oxide
• Solvent-free condition