One-pot synthesis of functionalized thiazolidine-4-ones from thiosemicarbazone derivatives and activated acetylenes in water as a green solvent

Authors

• Sayed Ali Ahmadi ¹
• Dadkhoda Ghazanfari ²

1. Department of Chemistry, Faculty of Science, Kerman Branch, Islamic Azad University, Kerman, Iran.
2. Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran.

Abstract

Some 2-iminothiazolidin-4-ones have been synthesized by the reaction of dialkyl acetylenedicarboxylates with thiosemicarbazones. The reaction was performed in the presence of 10 mol% of triphenylphosphine and tetrabutylammonium bromide as a phase transfer catalyst in water as a green solvent. All the synthesized compounds were characterized by their physical and spectral data.

Keywords

• Triphenyl phosphine
• Tetrabutyl ammonium bromide.
• Dialkyl acetylenedicarboxylate
• Thiosemicarbazone
• Thiazolidine-4-ones