Nano-Silica phosphoric acid: an efficient catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (thiones) under solvent-free or sonication conditions

Authors

• Abdolhamid Bamoniri ¹
• Bi Bi Fatemeh Mirjalili ²
• Sedigheh Nazemian ³

1. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran
2. Department of Chemistry, College of Science, Yazd University, Yazd, P.O. Box 89195-741, Iran
3. Department of Chemistry, College of Science, Yazd University, I. R. Iran .

Abstract

Two simple protocols for the synthesis of three-component condensation reaction of an aldehyde, β-ketoester and urea or thiourea to obtain the 3, 4-dihydropyrimidin-2(1H)-ones (thiones) using nano silica phosphoric acid are reported. Short reaction times, high yields, reusability of catalyst and easy workup are some advantages of these protocols.

Keywords

• Heterogeneous catalyst. Multi-component reactions
• Nano silica phosphoric acid
• Biginelli reaction
• 4-Dihydropyrimidin-2(1H)-ones
• 4-Dihydropyrimidin-2(1H)-thiones