Highly efficient synthesis of carboacyclic nucleosides catalyzed by zinc oxide in 1-butyl-3-methylimidazolium bromide (ZnO/[bmim]Br)

Authors

• Tarlan Salehi-Hamzehkhani ¹
• Marzieh Hatami ¹
• Abdolkarim Zare ²
• Ahmad Reza Moosavi-Zare ³
• Abolfath Parhami ¹
• Zahra Khedri ¹
• Hamideh Kabgani ¹
• Mohammad Beikagha ¹
• Raheleh Salamipoor ¹

1. Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Iran.
2. Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran
3. Department of Chemistry, Sayyed Jamaleddin Asadabadi University, Asadabad, 6541861841, Iran.

Abstract

Michael addition of pyrimidine and purine nucleobases to substituted as well as unsubstituted α,β-unsaturated esters efficiently proceeds in the presence of catalytic amount of zinc oxide in ionic liquid 1-butyl-3-methylimidazolium bromide (ZnO/[bmim]Br) under microwave irradiation to afford carboacyclic nucleosides, as biologically important compounds, in good to excellent yields and in short reaction times.

Keywords

• Ionic liquid
• Microwave irradiation
• Carboacyclic nucleoside
• Michael addition
• Zinc oxide
• 1-Butyl-3-methylimidazolium bromide ([bmim]Br)