Highly efficient multicomponent Biginelli’s synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by Al-MCM-41 under solvent-free conditions

Authors

• Soheil Sayyahi ¹
• Mehdi Behvandi Behvandi ²

1. Department of Chemistry, Mahshahr Branch, Islamic Azad University, Mahshahr, Iran.
2. Department of Chemistry, College of Chemical Engineering, Mahshahr Branch, Islamic Azad University, Mahshahr, Iran.

Abstract

In this study, an efficient and green process for the synthesis of dihydropyrimidin-2(1H)-ones from aromatic benzaldehydes, ethyl acetoacetate and urea using Al-MCM-41 as heterogeneous catalyst and microreactor under solvent-free conditions has been developed. The advantages of this method are easy work-up procedure, regeneration of the catalyst, clean and neutral reaction conditions.

Keywords

• Heterogeneous catalyst
• Biginelli reaction
• Al-MCM-41
• Dihydropyrimidinones