Cellulose sulfuric acid catalyzed multicomponent reaction for efficient synthesis of pyrimido and pyrazolo[4,5-b]quinolines under solvent-free conditions

Authors

• Seyyedeh Cobra Azimi ¹

• Young Researchers and Elites Club, Rasht Branch, Islamic Azad University, Rasht, Iran.

Abstract

Cellulose sulfuric acid was used as an efficient biopolymer-based catalyst for the synthesis of tetrahydropyrimido[4,5-b]quinoline-2,4,6-triones and hexahydro-2H-pyrazolo[5,4-b]quinoline-6-ones via three component reaction of aldehyde, 5,5-dimethyl-1,3-cyclohexadione and 6-amino-1,3-dimethyluracil or 5-amino-3-methyl-1-phenypyrazole under solvent-free conditions at 90 oC. The major advantages of the present method are simple experimentation, use of inexpensive and eco-friendly reusable catalyst with good yields and short reaction times.

Keywords

• 6-Amino-1
• 3-dimethyluracil
• 5-Amino-3-methyl-1-phenypyrazole
• Cellulose sulfuric acid
• Solvent-free