A facile one-pot four-component synthesis of dihydropyrrol-2-ones using Cl3CCO2H

Authors

• Nourallah Hazeri ¹
• Malek Taher Maghsoodlou ¹
• Sajad Mohamadian-Souri ²
• Mojtaba Lashkari ³
• Majid Ghashang ⁴

1. Chemistry Department, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran
2. Department of Chemistry, Faculty of Science, University of Sistan & Baluchestan, P. O. Box 98135-674 Zahedan, Iran
3. Faculty of Science, Velayat University, Iranshahr, Iran.
4. Department of Chemistry, Najafabad Branch, Islamic Azad University, P.O. Box: 517; Najafabad, Iran

Abstract

A convenient synthesis of different types of polyfunctional dihydropyrrol-2-ones via one-pot four component reactions of formaldehyde, dialkyl acetylenedicarboxylates and amines, catalyzed by trichloroacetic acid (Cl3CCO2H) at room temperature has been investigated. The significant advantages of this synthetic method are mild reaction conditions, available and inexpensive material, short reaction times, good yields, simple work-up.

Keywords

• amine
• Dihydro-2-oxypyrroles
• Dialkyl acetylenedicarboxylate
• Aldehyde