Interaction of cationic phosphorus dendrimers with lipid membranes

Ionov, M.; Wróbel, D.; Gardikis, K.; Hatziantoniou, S.; Demetzos, C.; Majoral, J. P.; Klajnert, B.; Bryszewska, M.

doi:10.7508/ijnd.2011.01.007

Original Article

Interaction of cationic phosphorus dendrimers with lipid membranes

Authors

Department of General Biophysics, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland.
Department of Pharmaceutical Technology, School of Pharmacy University of Athens, Panepistimiopolis, Zografou 15771, Athens, Greece.
Pharmaceutical Technology, School of Pharmacy University of Athens, Panepistimiopolis, Zografou 15771, Athens, Greece.
Laboratorie de Chimie de Coordination, CNRS, UPR 8241 205, route de Narbonne 31077, Toulouse, France.

Abstract

Large unilamellar liposomes and multilamellar vesicles consisting of DMPC interacted with cationic phosphorus-containing dendrimers CPDs G3 and G4. DSC and ζ -potential measurements have shown that liposomal-dendrimeric molecular recognition occurs due to the interaction between the complementary surface groups. Calorimetric studies indicate that the enthalpy of the transition of the lipids that interact with CPDs is dependent on the dendrimers generation. These results can be used in order to rationally design mixed modulatory liposomal locked-in dendrimeric, drug delivery nano systems.