Cytotoxic properties (MDA-MB-231- an epithelial breast cancer cell line) and bactericidal activity of Silver nanoparticles mediated by Strobilanthes ciliata nees

Authors

• Vasanth Nayagam * ^{1, 2}
• Abitha Ponnambalam ^{1, 2}
• Joelri Michael Raj Lourdhurajan ¹
• Anthony Samy ¹
• Savarimuthu Ignacimuthu ³

1. Dept of Botany, St. Xavier’s College, Palayamkottai, Tirnelveli, Tamilnadu, India (Affiliated to Manonmaniam Sundaranar University).
2. Dept of Botany, Alagappa Univeristy,Karaikudi, Tamilnadu, India.
3. The Anna and Donald Waite Chair, Creighton University, Omaha, USA.

Abstract

The sciences that intrigue about nanotechnology are increased ever before and improved permeability in its applications at various arenas. Precisely, the Silver nanoparticles (AgNPs) implication is deep-time perspective to understand that fascinating nanomaterials are involved in different biomedical applications. Since NPs application derivates are physical and chemical based but biological methods is still holds a profound impact. Hence, the medicinal plant Strobilanthes ciliata was utilized to synthesis AgNPs and the same was subjected to UV irradiation. And subsequent application of the crude biosynthesis of AgNPs was experimented with various physico-chemical parameters. Biosynthesized particle characterization was carried out by color pattern and UV-visible spectroscopy and followed by FTIR, SEM and finally experimenting with cancer cells as cyto-toxic study. The characterization result of particle size of synthesized AgNPs is 77 nm. The highest peak obtained in FTIR is at 3439.48cm−1 (OH) and the UV range is 477 nm. As far as the cancer cells are concerned, the cell survival rate at 1 mcg is 62% and at 1.5 mcg is 30% which is optimal. The lattice planes of XRD are face-centered-cubic (FCC) structure. The Particle size of S.ciliata mediated AgNPs is 77.7 nm. Biological methods attain much concern and forethought because bio-resources are used as precursors in synthesis of NPs. Therefore, herein we exclusively have done the plant-mediated metallic NPs synthesis, characterization and applications in detailed summary.  The present research observation will hold enrich understanding about AgNPs interaction and the mode of synthesis with various expertise and subject.

Graphical Abstract

Keywords

• Green chemistry
• Nanomaterials
• Strobilanthes Ciliata.
• Cancer cells
• Characterization

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