Application effect of continuous renal replacement therapy combined with hemoperfusion in patients with acute severe organophosphorus pesticide poisoning

Cheng, Xiaorong; Yang, Haiyang; Wu, Jun; Wang, Li; Wu, Tingting; Chen, Yuhong

doi:10.57647/j.ijic.2023.1401.01

Original Article

Application effect of continuous renal replacement therapy combined with hemoperfusion in patients with acute severe organophosphorus pesticide poisoning

Authors

Abstract

Objective: To probe the effect of continuous renal replacement therapy (CRRT) associated with Hemoperfusion in acute severe organophosphorus pesticide poisoning (ASOPP) patients.

Methods: A total of 58 ASOPP patients admitted to our hospital from January 2018 to December 2022 were selected and grouped into a control group (CG, n=29) and a research group (RG, n=29) according to the random number table method. Both groups received conventional treatment, and the RG received CRRT combined with hemoperfusion therapy. It compared (1) curative effect, (2) coma time, (3) choline recovery time, (4) atropine dosage, (5) ICU stay time, (6) serum levels of IL-4 together with TNF-α, (7) occurrence of intermediate syndrome, (8) mortality, and (9) SOFA scores in both groups.

Results: The total effective rate in the RG was elevated compared to the CG (P<0.05). The coma time, choline recovery time, and ICU stay time of the RG were shorter compared to the CG, and the atropine dosage of the RG declined compared to the CG (P<0.05). After treatment, both levels were elevated in 2 groups, and those in the RG were lower than the CG (P<0.05). After treatment, in 2 groups, those in the RG declined relative to the CG (P<0.05) lessened SOFA scores.

Conclusion: CRRT combined with Hemoperfusion can play a positive role in ASOPP, which can improve the clinical therapeutic effect, effectively control the inflammatory response, and shorten the clinical rescue and treatment time of patients, which is worth popularizing and using in the clinic.