A review of advances in coaxial Electrospinning for drug delivery

Authors

• Mahasa Haseli ¹
• Akbar Esmaeili * ²

1. Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Bell Engineering Center, AR, USA
2. Department of Chemical Engineering, North Tehran Branch, Islamic Azad University, Tehran, Iran

Abstract

Nanofibrous scaffolds are employed as drug carriers in the healthcare industry. Coaxial Electrospinning is a method for preparing core–shell nanofibers cost-effectively and efficiently in which the drugs or bioactive components are encapsulated into a body covered by a shell layer. The coaxial electrospun nanofiber morphology is affected by solution properties, process parameters, and environment parameters. Therefore, Coaxial electrospun nanofibers have been developed for more sustained drug release due to their well-controlled drug release rate, low cost, and reduced toxicity. This paper provides a concise incursion into the application of coaxial electrospun nanofibers in drug delivery and cites pertinent processing parameters that may influence the performance of the nanofibers and drug release when applied to drug delivery. One of the critical challenges in producing nanofibers is finding methods that have sufficient speed for producing industrial textiles. Polymeric drug delivery systems can improve therapeutic efficacy, reduce toxicity, and increase patient compliance by delivering drugs at a controlled rate over some time in an active setting.

Keywords

• Coaxial Electrospinning
• Core-shell
• Drug delivery