D-phenyl alanine-oxalic acid (D-Phe-Ox): A novel nano ionic liquid catalyzing the one-step green synthesis of functionalized spirolactones and dispirodihydro-furanyl oxindoles

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  • Kobra Nikoofar*1,
  • Shiva Khani2,
  1. Department of Chemistry, Faculty of Physics & Chemistry, Alzahra University, Tehran, Iran
  2. Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Vanak, P.O. Box 1993893973, Tehran, Iran.

Published in Issue 2024-02-03

How to Cite

Nikoofar, K., & Khani, S. (2024). D-phenyl alanine-oxalic acid (D-Phe-Ox): A novel nano ionic liquid catalyzing the one-step green synthesis of functionalized spirolactones and dispirodihydro-furanyl oxindoles. Iranian Journal of Catalysis, 8(4). https://oiccpress.com/ijc/article/view/4019

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Abstract

In this paper, a new nano-size ionic liquid (nIL) has been synthesized from D-phenylalanine and oxalic acid (D-Phe-OX) via a simple procedure. The obtained nIL has been characterized by the fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDAX), thermogravimetric analysis (TGA), nuclear magnetic resonance spectroscopy (1H NMR), and field emission scanning electron microscopy (FESEM), techniques. The synthesized nanocatalyst has been used for the three-component one-step synthesis of functionalized spirolactones via the condensation reaction of arylamines, DMAD and isatins. The stereoselective preparation of dispirodihydrofuranyl oxindoles has also been examined successfully through the one-step pseudo-four component condensation of isatins, amines and DMAD, respectively.

Keywords

  • Chiral. Isatin,
  • Dispirodihydrofuranyl oxindole,
  • DMAD,
  • Nano ionic liquid,
  • Spirolactone
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