Synthesis of dihydrofurans using biosynthesized CuO nanoparticles

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  • Javad Safaei-Ghomi*1,
  • Hossein Shahbazi-Alavi2,
  1. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, I. R. Iran
  2. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, 51167 Kashan, I. R. Iran.

Published in Issue 2024-02-03

How to Cite

Safaei-Ghomi, J., & Shahbazi-Alavi, H. (2024). Synthesis of dihydrofurans using biosynthesized CuO nanoparticles. Iranian Journal of Catalysis, 8(4). https://oiccpress.com/ijc/article/view/4017

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Abstract

The preparation of trans-dihydrofurans has been achieved by a one-pot condensation reaction of 4-bromophenacyl bromide, aromatic aldehydes and 5,5-dimethyl-1,3-cyclohexanedione using biosynthesized CuO nanoparticles under reflux conditions in ethanol. CuO nanoparticles (CuO NPs) were prepared using extractof leaves of Ajuga chamaecistus Subsp. Scoparia. The key advantages of this process are the diastereoselective synthesis, reusability of the catalyst, low catalyst loading, excellent yields, short reaction times, simple workup and environmentally benign. Fully optimized structures of trans and cis dihydrofurans were obtained by B3LYP/6-31G(d,p) method. The structures of the prepared trans-2,3-dihydrofurans were fully characterized by 1H and 13C NMR spectra, IR spectra, and elemental analysis.

Keywords

  • Biosynthesized CuO nanoparticles,
  • Dihydrofurans,
  • Green synthesis,
  • One-pot,
  • Reusable catalyst.
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