Synthesis, characterization and catalytic application of Fe3O4@CysâSO3H for preparation of 2H-indazolo[1,2-b]phthalazine-triones

Abstract

The surface ofFe₃O₄ magnetic nanoparticles (MNPs) was modified by L-cysteine through condensation of COOH groups of L-cysteine and OH groups on the surface of Fe₃O₄. The âSH group of preparedFe₃O₄@Cys MNPs oxidized to âSO₃H group and Fe₃O₄@CysâSO₃H as an environmentally friendly magnetic nanoparticle was prepared. The MNPs were characterized by FT-IR, XRD, SEM and TEM studies. Then, the catalytic activity of the MNPs was evaluated as an effective and reusable catalyst for one-pot synthesis of 2Hâindazolo [1,2âb] phthalazineâtriones derivatives. The results show that the catalytic activity of Fe₃O₄@CysâSO₃H was comparable to that of other reported heterogeneous and homogeneous catalysts.