Magnetic nanosphere [email protected] promoted synthesis of 5-substituted 1H-tetrazoles

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  • Bi Bi Fatemeh Mirjalili1,
  • Hadise Jorsarraie2,
  • Hamidreza Akrami3,
  1. Department of Chemistry, College of Science, Yazd University, Yazd, P.O. Box 89195-741, Iran
  2. Department of Chemistry, College of Science, Yazd University, Yazd. P.O. Box 89195-741, Iran.
  3. Young Researcher and Elite Club, Yazd Branch, Islamic Azad University, Yazd, Islamic Republic of Iran.

Published in Issue 2024-02-03

How to Cite

Mirjalili, B. B. F., Jorsarraie, H., & Akrami, H. (2024). Magnetic nanosphere [email protected] promoted synthesis of 5-substituted 1H-tetrazoles. Iranian Journal of Catalysis, 7(3). https://oiccpress.com/ijc/article/view/3969

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Abstract

Tetrazoles have many interesting futures and applications in drug and energy industries. 5-Substituted 1H-tetrazoles were synthesized via [2+3] cycloaddition reaction of aryl or alkyl nitriles with sodium azide in the presence of Fe3O4@SiO2.SnCl4 as catalyst in DMF under reflux conditions.  The catalyst was removed from reaction mixture by an external magnet and was reusable for many times without any appreciable loss of its activity. The Fe3O4@SiO2.SnCl4 promotes synthesis of tetrazole in shorter time than other reported catalysts. The obtained tetrazoles were identified by spectroscopic and physical data such as FT-IR, 1HNMR and melting point. Easy workup and reusability of catalyst are some advantages of this protocol.

Keywords

  • 1H-tetrazoles,
  • [email protected],
  • Magnetic catalyst. Lewis acid catalyst,
  • Organonitrile compounds,
  • Sodium azide
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