Oxalic acid dihydrate catalyzed synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives under thermal and solvent-free conditions

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  • Farzaneh Mohamad Pour1,
  • Malek Taher Maghsoodlou2,
  • Reza Heydari3,
  • Mojtaba Lashkari4,
  1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran.
  2. Chemistry Department, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran
  3. Department of Chemistry, the University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran.
  4. Faculty of Science, Velayat University, Iranshahr, Iran.

Published in Issue 2024-02-03

How to Cite

Mohamad Pour, F., Maghsoodlou, M. T., Heydari, R., & Lashkari, M. (2024). Oxalic acid dihydrate catalyzed synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives under thermal and solvent-free conditions. Iranian Journal of Catalysis, 6(2). https://oiccpress.com/ijc/article/view/3895

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Abstract

Oxalic acid dihydrate as a green, mild and efficient catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives from the reaction between β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea under thermal and solvent-free conditions with excellent yields and short reaction time is studied. The most remarkable benefits of this synthetic method include the green methodology, an eco-friendly, inexpensive and non-toxic catalyst, solvent-free conditions, the availability of materials, and a simple operational procedure with no column chromatographic separation. The products were characterized by melting points, IR and 1H NMR spectroscopy.

Keywords

  • 4-Dihydropyrimidinone.,
  • Biginelli reaction,
  • Green methodology,
  • Oxalic acid.2H2O
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