Highly efficient multicomponent Biginelliâs synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by Al-MCM-41 under solvent-free conditions

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  • Soheil Sayyahi1,
  • Mehdi Behvandi Behvandi2,
  1. Department of Chemistry, Mahshahr Branch, Islamic Azad University, Mahshahr, Iran.
  2. Department of Chemistry, College of Chemical Engineering, Mahshahr Branch, Islamic Azad University, Mahshahr, Iran.

Published in Issue 2024-02-03

How to Cite

Sayyahi, S., & Behvandi, M. B. (2024). Highly efficient multicomponent Biginelli’s synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by Al-MCM-41 under solvent-free conditions. Iranian Journal of Catalysis, 5(2). https://oiccpress.com/ijc/article/view/3846

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Abstract

In this study, an eï¬cient and green process for the synthesis of dihydropyrimidin-2(1H)-ones from aromatic benzaldehydes, ethyl acetoacetate and urea using Al-MCM-41 as heterogeneous catalyst and microreactor under solvent-free conditions has been developed. The advantages of this method are easy work-up procedure, regeneration of the catalyst, clean and neutral reaction conditions.

Keywords

  • Al-MCM-41,
  • Biginelli reaction,
  • Dihydropyrimidinones,
  • Heterogeneous catalyst
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