Tetramethylguanidiniumtriflate catalyzed Henry reaction of isatins: An efficient synthesis of 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives and their anti-diabetic activity

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  • Leila Youseftabar-Miri1,
  • Maryam Rafieirad2,
  1. Department of Chemistry, Izeh Branch, Islamic Azad University, Izeh, Iran
  2. Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran

Published in Issue 2024-02-03

How to Cite

Youseftabar-Miri, L., & Rafieirad, M. (2024). Tetramethylguanidiniumtriflate catalyzed Henry reaction of isatins: An efficient synthesis of 3-hydroxy-3-(nitromethyl)indolin-2-one derivatives and their anti-diabetic activity. Iranian Journal of Catalysis, 5(1). https://oiccpress.com/ijc/article/view/3827

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Abstract

The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-diabetic activity.(The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-diabetic activity, i try to submit paper)

Keywords

  • Henry reaction,
  • Ionic liquid,
  • Isatin,
  • Oxindole
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