Green and diastereoselective synthesis of trans-3-(5-methylisoxazol-3-yl)-3,4-dihydro-2H-naphtho[2,3-e][1,3]oxazines

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  • Mehdi Shafiee1,
  • Ahmad Reza Khosropour2,
  • Iraj Mohammadpoor-Baltork2,
  • Majid Moghadam2,
  • Shahram Tangestaninejad2,
  • Valiollah Mirkhani2,
  • Hamid Reza Khavasi3,
  1. Chemistry Department, Malek-ashtar University of Technology, Shahin-shahr, 83145-115, Iran.
  2. Catalysis Division, Department of Chemistry, Faculty of Science, University of Isfahan, Isfahan 81746-7344, Iran.
  3. Department of Chemistry, Shahid Beheshti University, Evin, Tehran 1983963113, Iran.

Published in Issue 2024-02-03

How to Cite

Shafiee, M., Khosropour, A. R., Mohammadpoor-Baltork, I., Moghadam, M., Tangestaninejad, S., Mirkhani, V., & Khavasi, H. R. (2024). Green and diastereoselective synthesis of trans-3-(5-methylisoxazol-3-yl)-3,4-dihydro-2H-naphtho[2,3-e][1,3]oxazines. Iranian Journal of Catalysis, 4(3). https://oiccpress.com/ijc/article/view/3802

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Abstract

Reaction between aromatic aldehydes and 3âmethyl-1-phenyl-2-pyrazoline-5-one catalyzed by nano-SiO2/HClO4 in water under reflux provided a simple and efficient route for the synthesis of 4-((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(aryl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol derivatives in high yields.

Keywords

  • 3-e][1,
  • 3]oxazines,
  • Aryl aldehydes,
  • Betti base,
  • Dihydro-2H-naphtho[2,
  • Green chemistry,
  • p-TSA
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