Facile and mild synthesis of 1-substituted-1H-1,2,3,4-tetrazoles catalyzed by methanesulfonic acid under solvent-free conditions

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  • Hossein Naeimi1,
  • Fatemeh Kiani2,
  • Mohsen Moradian3,
  1. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, 87317-51167, I.R. Iran.
  2. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, P.O. Box: 87317-51167, Kashan, I.R. Iran.
  3. Institute of Nanoscience and Nanotechnology, University of Kashan, Kashan, P.O. Box: 87317-51167, I.R. Iran.

Published in Issue 2024-02-03

How to Cite

Naeimi, H., Kiani, F., & Moradian, M. (2024). Facile and mild synthesis of 1-substituted-1H-1,2,3,4-tetrazoles catalyzed by methanesulfonic acid under solvent-free conditions. Iranian Journal of Catalysis, 3(4). https://oiccpress.com/ijc/article/view/3780

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Abstract

Methanesulfonic acid (MSA) was found to be an efficient catalyst for the synthesis of 1-substituted-1H-1,2,3,4-tetrazoles. A series of 1-substituted tetrazole compounds were synthesized from the reaction of various primary amines, sodium azide and triethyl orthoformate in the presence of catalytic amounts of MSA at room temperature. In this protocol, some of the tetrazole derivatives were synthesized in good to excellent yields and convenient reaction times. This method has the advantages of simple methodology and easy work-up.

Keywords

  • 1H-tetrazoles,
  • Methanesulfonic acid,
  • Primary amines.,
  • Room temperature,
  • Solvent-free
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