Synthesis and in-vitro antimicrobial screening of 3-cinnamoyl coumarin and 3-[3-(1H-indol-2-yl)-3-aryl-propanoyl]-2H-chromen-2-ones

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  • Somnath S. Gholap1,
  • Umesh P. Deshmukh1,
  • Macchindra S. Tambe1,
  1. Department of Chemistry, Padmashri Vikhe Patil College, Pravaranagar (Loni Kd), Tal- Rahata, Dist -Ahmednagar, Pin-413713,(MS), India.

Published in Issue 2024-02-03

How to Cite

Gholap, S. S., Deshmukh, U. P., & Tambe, M. S. (2024). Synthesis and in-vitro antimicrobial screening of 3-cinnamoyl coumarin and 3-[3-(1H-indol-2-yl)-3-aryl-propanoyl]-2H-chromen-2-ones. Iranian Journal of Catalysis, 3(3). https://oiccpress.com/ijc/article/view/3769

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Abstract

An efficient synthesis of some novel coumarin derivatives via 1, 4- Michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (CSA) under solvent free conditions is described. The corresponding Michael addition products were obtained in good to excellent yield. The synthesized compounds were screened for their antibacterial activity against E. coli, S. aureus and anti-fungal activity against C. albicans. All the synthesized compounds show moderate to good antimicrobial activity.

Keywords

  • 1. 4-Michael addition,
  • 3-acetyl coumarinn,
  • Antibacterial activity,
  • Cellulose sulphonic acid(CSA),
  • Chalcones,
  • indole
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