Facile one-pot multicomponent synthesis of 2-amino-6-(2-oxo-2H-chromen- 3-yl)-4-arylpyridine-3-carbonitriles using Brønsted acidic ionic liquid as catalyst under solvent-free conditions

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  • Janardhan Banothu1,
  • Rajitha Bavantula1,
  • Peter A. Crooks2,
  1. Department of Chemistry, National Institute of Technology, Warangal, A.P., India.
  2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Published in Issue 2024-02-03

How to Cite

Banothu, J., Bavantula, R., & Crooks, P. A. (2024). Facile one-pot multicomponent synthesis of 2-amino-6-(2-oxo-2H-chromen- 3-yl)-4-arylpyridine-3-carbonitriles using Brønsted acidic ionic liquid as catalyst under solvent-free conditions. Iranian Journal of Catalysis, 3(1). https://oiccpress.com/ijc/article/view/3751

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Abstract

A series of 2-amino pyridine-3-carbinitrile derivatives incorporated coumarin moiety has developed via multicomponent condensation of 3-acetyl-2H-chromen-2-one, arylaldehydes, malononitrile and ammonium acetate utilizing Brønsted acidic ionic liquid, (4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogen sulfate as catalyst under solvent-free conditions. Good yields, short reaction times, straight forward workup, reusability of the ionic liquid and green conditions are the most obvious advantages of this methodology.

Keywords

  • (4-Sulfobutyl)tris-(4-sulfophenyl)phosphonium hydrogen sulfate,
  • 2-Amino pyridine-3-carbinitrile,
  • 3-Acetyl-2H-chromen-2-ones,
  • Multicomponent condensation
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