A fast, simple and convenient procedure for the synthesis of fused pyrimidinone derivatives by using [Hmim][HSO4] as a green, efficient and reusable catalyst under solvent-free conditions

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  • Leila Khazdooz1,
  • Amin Zarei2,
  • Abdol R. Hajipour3,
  • Nafisehsadat Sheikhan4,
  1. Laser and Biophotonics in Biotechnologies Research Center, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan 81595-158, Iran
  2. Department of Science, Fasa Branch, Islamic Azad University, PO Box No. 364, Fasa 7461713591, Fars, Iran.
  3. Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532, WI, USA.
  4. Department of Chemistry, Faculty of Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Esfahan, P.O. Box 517, Iran.

Published in Issue 2024-02-03

How to Cite

Khazdooz, L., Zarei, A., Hajipour, A. R., & Sheikhan, N. (2024). A fast, simple and convenient procedure for the synthesis of fused pyrimidinone derivatives by using [Hmim][HSO4] as a green, efficient and reusable catalyst under solvent-free conditions. Iranian Journal of Catalysis, 2(4). https://oiccpress.com/ijc/article/view/3741

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Abstract

In the present of methylimidazolium hydrogen sulfate, the synthesis of arylidene heterobicyclic pyrimidinones is studied by condensation of aromatic aldehyde, cyclopentanone, and urea or thiourea. Using solvent-free conditions, non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method.

Keywords

  • Biginelli-type reaction,
  • Bronsted acidic ionic liquid,
  • Methylimidazolium hydrogen sulfate,
  • Pyrimidinone
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