An efficient one-pot synthesis of α-amino nitriles using ecofriendly Lewis-acidic ionic liquid choline chloride.2ZnCl2

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  • Abdol R. Hajipour1,
  • Ifa Mahboobi Dehbane2,
  1. Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532, WI, USA.
  2. Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran.

Published in Issue 2024-02-03

How to Cite

Hajipour, A. R., & Mahboobi Dehbane, I. (2024). An efficient one-pot synthesis of α-amino nitriles using ecofriendly Lewis-acidic ionic liquid choline chloride.2ZnCl2. Iranian Journal of Catalysis, 2(4). https://oiccpress.com/ijc/article/view/3737

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Abstract

α-Amino nitriles are synthesized in a one-pot, three-component coupling of aldehydes (or ketones), aniline, and trimethylsilyl cyanide using a catalytic amount of choline chloride.2ZnCl2 as a bio Lewis acidic ionic liquid. Mild Lewis acidic characteristic of this ionic liquid allows efficient synthesis of α-amino nitriles from acid sensitive aldehydes.

Keywords

  • Choline chloride,
  • Strecker reaction,
  • Trimethylsilylcyanide,
  • α-Amino nitriles
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