Nano-Silica phosphoric acid: an efficient catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (thiones) under solvent-free or sonication conditions

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  • Abdolhamid Bamoniri1,
  • Bi Bi Fatemeh Mirjalili2,
  • Sedigheh Nazemian3,
  1. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran
  2. Department of Chemistry, College of Science, Yazd University, Yazd, P.O. Box 89195-741, Iran
  3. Department of Chemistry, College of Science, Yazd University, I. R. Iran .

Published in Issue 2024-02-03

How to Cite

Bamoniri, A., Mirjalili, B. B. F., & Nazemian, S. (2024). Nano-Silica phosphoric acid: an efficient catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (thiones) under solvent-free or sonication conditions. Iranian Journal of Catalysis, 2(1). https://oiccpress.com/ijc/article/view/3715

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Abstract

Two simple protocols for the synthesis of three-component condensation reaction of an aldehyde, β-ketoester and urea or thiourea to obtain the 3, 4-dihydropyrimidin-2(1H)-ones (thiones) using nano silica phosphoric acid are reported. Short reaction times, high yields, reusability of catalyst and easy workup are some advantages of these protocols.

Keywords

  • 4-Dihydropyrimidin-2(1H)-ones,
  • 4-Dihydropyrimidin-2(1H)-thiones,
  • Biginelli reaction,
  • Heterogeneous catalyst. Multi-component reactions,
  • Nano silica phosphoric acid
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