10.57647/tpr.2025.0902.12

Isolation and characterization of phytoconstituents and exploration of in vitro and in vivo biological activities of Anaxagorea luzonensis A. Gray (Annonaceae)

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  • Sabiha Rahman1,
  • Fatema-Tuz-Zohora1,
  • Ramisa Anjum1,
  • A.H.M Nazmul Hasan1,
  • Mohiuddin Ahmed Bhuiyan1,
  • Choudhury Mahmood Hasan2,
  • Mohammad Shahriar*1,
  1. Phytochemistry Research Laboratory, Department of Pharmacy, University of Asia Pacific, Dhaka-1205, Bangladesh
  2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

Received: 2025-02-17

Revised: 2025-06-19

Accepted: 2025-06-23

Published in Issue 2025-09-27

Published Online: 2025-06-25

Copyright (c) 2025 Sabiha Rahman, Fatema-Tuz-Zohora, Ramisa Anjum, A.H.M Nazmul Hasan, Mohiuddin Ahmed Bhuiyan, Choudhury Mahmood Hasan, Mohammad Shahriar (Author)

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Rahman, S., -Zohora, F.-T., Anjum, R., Nazmul Hasan, A., Bhuiyan, M. A., Mahmood Hasan, C., & Shahriar, M. (2025). Isolation and characterization of phytoconstituents and exploration of in vitro and in vivo biological activities of Anaxagorea luzonensis A. Gray (Annonaceae). Trends in Phytochemical Research, 9(2). https://doi.org/10.57647/tpr.2025.0902.12
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Abstract

This study aimed to evaluate the α-glucosidase inhibition potential of Prosopis farcta and Rheum ribes. For this purpose, various plant parts—including the root bark, roots, fruits, and leaves of P. farcta, as well as the roots and stalks of R. ribes—were sequentially extracted employing n-hexane, ethyl acetate, and methanol. The α-glucosidase inhibition potential of the extracts was assessed. Subsequently, the phytochemical investigation was carried out on the ethyl acetate extract derived from the root of P. farcta, which exhibited the most pronounced inhibitory effect. This analysis resulted in the isolation and identification of six compounds, including four steroids, one pentacyclic triterpenoid, and one flavonoid. The isolated compounds underwent further evaluation for their α-glucosidase inhibition potential. Among them, daucosterol (3) demonstrated the highest potency, with an IC50 value of 18.6 µM.

 

Keywords

  • Anaxagorea luzonensis A. Gray,
  • Annonaceae,
  • Antioxidant,
  • Analgesic,
  • Antipyretic,
  • Cytotoxic,
  • Phytoconstituents,
  • Spinasterol
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