10.1007/s40097-021-00394-w

Self-assembled membrane-polymer nanoparticles of top-notch tissue tolerance for the treatment of gastroesophageal reflux disease

Show Details XML
  • Onyekachi Oluchi Enwereuzo1,
  • Obinna Chigoziem Akakuru2,
  • Romanus Chinonso Uwaoma3,
  • Elias Emeka Elemike4,
  • Ozioma Udochukwu Akakuru*5,
  1. Department of Geography and Environmental Management, Imo State University, Owerri, NG
  2. Department of Geology, Federal University of Technology Owerri, Owerri, NG
  3. Center of Excellence in Carbon-Based Fuels, North-West University, Potchefstroom Campus, Potchefstroom, 2520, ZA
  4. Department of Chemistry, College of Science, Federal University of Petroleum Resources Effurun, Delta State, NG
  5. Department of Pure and Applied Chemistry, University of Calabar, Calabar, NG Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, CN

Published in Issue 03-03-2021

How to Cite

Enwereuzo, O. O., Akakuru, O. C., Uwaoma, R. C., Elemike, E. E., & Akakuru, O. U. (2021). Self-assembled membrane-polymer nanoparticles of top-notch tissue tolerance for the treatment of gastroesophageal reflux disease. Journal of Nanostructure in Chemistry, 11(4 (December 2021). https://doi.org/10.1007/s40097-021-00394-w
Crossref
Scopus
Google Scholar
Europe PMC

Abstract

Abstract Controlled release technology has continuously attracted attention as a strategy to deliver active agents to specific internal body regions with attendant cost-effectiveness among other intriguing merits. Here, drug-loaded nanoparticles (NPs) are synthesized for ultimate application in the treatment of gastroesophageal reflux disease (GERD), leveraging the benefits of controlled release strategy. To achieve this, eggshell membranes (ESMs) were extracted and combined with chitosan (CHS) to rationally obtain self-assembled CHS–ESM NPs that served as a novel nanocarrier to effectively compartmentalize a GERD-therapeutic drug famotidine (FTD) and form self-assembled FTD@CHS–ESM NPs. Advantageously, the proof-of-concept FTD@CHS–ESM NPs offer superlative tissue tolerance. The cumulative FTD release is 89% after 12 h at pH 1.2, suggesting the capability of FTD@CHS–ESM NPs for effectual controlled drug release; a testimonial of the effective compartmentalization of FTD in the nanocarrier. Furthermore, the release of FTD from the FTD@CHS–ESM NPs is best described by Higuchi square root model, in a non-Fickian diffusional release mechanism ( n  = 0.584 and 0.582 in pH 1.2 and pH 6.8, respectively). The drug release system demonstrated in this work, therefore, holds strong promise for the oral nanomedical treatment of GERD in vivo, and promotes the rational synthesis of organic-based biocompatible nanomaterials for biomedical application. Graphic abstract

Keywords

  • Chitosan,
  • Eggshell membrane,
  • Famotidine,
  • GERD,
  • Slow drug release

References

  1. Satapathy et al. (2010) Evaluation of anti-GERD activity of gastro retentive drug delivery system of itopride hydrochloride 38(4) (pp. 200-207) https://doi.org/10.3109/10731191003776751
  2. Kim et al. (2005) Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study 11(27) (pp. 4210-4214) https://doi.org/10.3748/wjg.v11.i27.4210
  3. MacFarlane (2018) Management of gastroesophageal reflux disease in adults: a pharmacist's perspective (pp. 41-52) https://doi.org/10.2147/IPRP.S142932
  4. Wulf et al. (2004) Stereotactic radiotherapy for primary lung cancer and pulmonary metastases: a noninvasive treatment approach in medically inoperable patients 60(1) (pp. 186-196) https://doi.org/10.1016/j.ijrobp.2004.02.060
  5. Cocuzza et al. (2014) Relationship between radiotherapy and gastroesophageal reflux disease in causing tracheoesophageal voice rehabilitation failure 28(2) (pp. 245-249) https://doi.org/10.1016/j.jvoice.2013.08.008
  6. Boscolo-Rizzo et al. (2008) The impact of radiotherapy and GERD on in situ lifetime of indwelling voice prostheses 265(7) (pp. 791-796) https://doi.org/10.1007/s00405-007-0536-1
  7. Taha et al. (2009) Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial 374(9684) (pp. 119-125) https://doi.org/10.1016/S0140-6736(09)61246-0
  8. Wu et al. (2010) Histamine2-receptor antagonists are an alternative to proton pump inhibitor in patients receiving clopidogrel 139(4) (pp. 1165-1171) https://doi.org/10.1053/j.gastro.2010.06.067
  9. Lamson et al. (2020) Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability 4(1) (pp. 84-96) https://doi.org/10.1038/s41551-019-0465-5
  10. Mokhtar et al. (2017) Design of PEG-grafted-PLA nanoparticles as oral permeability enhancer for P-gp substrate drug model Famotidine 34(1) (pp. 91-103) https://doi.org/10.1080/02652048.2017.1290155
  11. Shafique et al. (2017) Fabrication, characterization, and in vivo evaluation of famotidine loaded solid lipid nanoparticles for boosting oral bioavailability https://doi.org/10.1155/2017/7357150
  12. Lai et al. (2009) Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues 61(2) (pp. 158-171) https://doi.org/10.1016/j.addr.2008.11.002
  13. Shirvani et al. (2014) Mobility and efficacy of 2,4-D herbicide from slow-release delivery systems based on organo-zeolite and organo-bentonite complexes 49(4) (pp. 255-262) https://doi.org/10.1080/03601234.2014.868275
  14. Akakuru and Onyido (2021) Controlled release formulations of 2,4-dichlorophenoxyacetic acid with ecofriendly matrices for agricultural and environmental sustainability 29(1) (pp. 40-53) https://doi.org/10.1007/s13233-021-9004-9
  15. Lee, P.I., Li, J.X.: Evolution of oral controlled release dosage forms. In: Oral controlled release formulation design and drug delivery: theory to practice, pp. 21–31 (2010).
  16. https://doi.org/10.1002/9780470640487.ch2
  17. Yun et al. (2015) Controlled drug delivery: historical perspective for the next generation (pp. 2-7) https://doi.org/10.1016/j.jconrel.2015.10.005
  18. Akakuru and Isiuku (2017) Chitosan hydrogels and their glutaraldehyde-crosslinked counterparts as potential drug release and tissue engineering systems—synthesis, characterization, swelling kinetics and mechanism https://doi.org/10.4172/2161-0398.100025
  19. Akakuru et al. (2019) Facile fabrication of pH-responsive and swellable slow release microparticles of chlorpheniramine maleate with chitosan-starch matrices and their crosslinks 69(5) (pp. 1-15) https://doi.org/10.1080/00914037.2018.1563084
  20. Akakuru et al. (2019) Novel highly-swellable and pH-responsive slow release formulations of clotrimazole with chitosan-g-PEG/starch microparticles (pp. 32-43) https://doi.org/10.1016/j.reactfunctpolym.2018.12.004
  21. Lin et al. (2015) Cupreous complex-loaded chitosan nanoparticles for photothermal therapy and chemotherapy of oral epithelial carcinoma 7(37) (pp. 20801-20812) https://doi.org/10.1021/acsami.5b05866
  22. Pandya et al. (2020) Drug-loaded photosensitizer-chitosan nanoparticles for combinatorial chemo- and photodynamic-therapy of cancer 21(4) (pp. 1489-1498) https://doi.org/10.1021/acs.biomac.0c00061
  23. Chamundeeswari et al. (2019) Nanocarriers for drug delivery applications 17(2) (pp. 849-865) https://doi.org/10.1007/s10311-018-00841-1
  24. Akakuru et al. (2019) The transition from metal-based to metal-free contrast agents for T1 magnetic resonance imaging enhancement 30(9) (pp. 2264-2286) https://doi.org/10.1021/acs.bioconjchem.9b00499
  25. de Queiroz Antonino et al. (2017) Preparation and characterization of chitosan obtained from shells of shrimp (Litopenaeus vannamei Boone) https://doi.org/10.3390/md15050141
  26. Verma et al. (2020) Carbohydrate and protein based biopolymeric nanoparticles: current status and biotechnological applications (pp. 390-412) https://doi.org/10.1016/j.ijbiomac.2020.03.105
  27. Akakuru et al. (2020) Self-assembled, biocompatible and biodegradable TEMPO-conjugated nanoparticles enable folate-targeted tumor magnetic resonance imaging https://doi.org/10.1016/j.apmt.2019.100524
  28. Akakuru et al. (2018) The chemistry of chitin and chitosan justifying their nanomedical utilities https://doi.org/10.4172/2167-0501.1000241
  29. Akakuru et al. (2018) Utility of nanomedicine for cancer treatment https://doi.org/10.4172/2157-7439.1000481
  30. Guha Ray et al. (2018) Surface modification of eggshell membrane with electrospun chitosan/polycaprolactone nanofibers for enhanced dermal wound healing 1(4) (pp. 985-998) https://doi.org/10.1021/acsabm.8b00169
  31. Jia et al. (2012) Preparation and characterization of soluble eggshell membrane protein/plga electrospun nanofibers for guided tissue regeneration membrane https://doi.org/10.1155/2012/282736
  32. Nys et al. (2004) Avian eggshell mineralization: biochemical and functional characterization of matrix proteins 3(6–7) (pp. 549-562) https://doi.org/10.1016/j.crpv.2004.08.002
  33. Nys et al. (2001) Biochemical and functional characterisation of eggshell matrix proteins in hens 57(4) (pp. 401-413) https://doi.org/10.1079/WPS20010029
  34. Santos et al. (2019) Thermal, chemical, biological and mechanical properties of chitosan films with powder of eggshell membrane for biomedical applications 136(2) (pp. 725-735) https://doi.org/10.1007/s10973-018-7666-0
  35. Choi et al. (2017) Preparation and characterization of eggshell membrane/PVA hydrogel via electron beam irradiation technique (pp. 41-45) https://doi.org/10.1016/j.jiec.2016.11.014
  36. Park and Kim (2017) Eggshell membrane: review and impact on engineering (pp. 446-463) https://doi.org/10.1016/j.biosystemseng.2016.10.014
  37. Lee and Huang (2019) Soluble eggshell membrane protein-loaded chitosan/fucoidan nanoparticles for treatment of defective intestinal epithelial cells (pp. 949-958) https://doi.org/10.1016/j.ijbiomac.2019.03.113
  38. Chai et al. (2013) Outer eggshell membrane as delivery vehicle for polysaccharide/protein microcapsules incorporated with vitamin E 61(3) (pp. 589-595) https://doi.org/10.1021/jf3040572
  39. Philip et al. (2009) Egg shell membrane as a substrate for optimizing in vitro transbuccal delivery of glipizide 14(5) (pp. 540-547) https://doi.org/10.1080/10837450902832893
  40. Akbari et al. (2015) The effect of Tween 20, 60, and 80 on dissolution behavior of sprionolactone in solid dispersions prepared by PEG 6000 5(3) (pp. 435-441) https://doi.org/10.15171/apb.2015.059
  41. Braun and Parrott (1972) Influence of viscosity and solubilization on dissolution rate 61(2) (pp. 175-178) https://doi.org/10.1002/jps.2600610206
  42. Akakuru et al. (2020) A Hybrid organo-nanotheranostic platform of superlative biocompatibility for near-infrared-triggered fluorescence imaging and synergistically enhanced ablation of tumors 16(41) https://doi.org/10.1002/smll.202002445
  43. Chen et al. (2013) Near-IR-triggered photothermal/photodynamic dual-modality therapy system via chitosan hybrid nanospheres 34(33) (pp. 8314-8322) https://doi.org/10.1016/j.biomaterials.2013.07.034
  44. Akakuru et al. (2021) Metal-free organo-theranostic nanosystem with high nitroxide stability and loading for image-guided targeted tumor therapy https://doi.org/10.1021/acsnano.0c09590
  45. Chen et al. (2015) Core–shell hybrid upconversion nanoparticles carrying stable nitroxide radicals as potential multifunctional nanoprobes for upconversion luminescence and magnetic resonance dual-modality imaging 7(12) (pp. 5249-5261) https://doi.org/10.1039/C4NR07591A
  46. Dash et al. (2010) Kinetic modeling on drug release from controlled drug delivery systems 67(3) (pp. 217-223)
  47. Shuai et al. (2020) A strawberry-like Ag-decorated barium titanate enhances piezoelectric and antibacterial activities of polymer scaffold https://doi.org/10.1016/j.nanoen.2020.104825
  48. Yang et al. (2021) Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold 6(5) (pp. 1230-1241) https://doi.org/10.1016/j.bioactmat.2020.10.017
  49. Verma et al. (2020) Chitin and chitosan-based support materials for enzyme immobilization and biotechnological applications 18(2) (pp. 315-323) https://doi.org/10.1007/s10311-019-00942-5
  50. Rad et al. (2019) Effect of antimicrobial photodynamic therapy using indocyanine green doped with chitosan nanoparticles on biofilm formation-related gene expression of Aggregatibacter actinomycetemcomitans 16(3) (pp. 187-193) https://doi.org/10.18502/fid.v16i3.1590
  51. Pourhajibagher et al. (2018) Monitoring of virulence factors and metabolic activity in Aggregatibacter actinomycetemcomitans cells surviving antimicrobial photodynamic therapy via nano-chitosan encapsulated indocyanine green https://doi.org/10.3389/fphy.2018.00124
  52. Jiang et al. (2019) Manganese-zeolitic imidazolate frameworks-90 with high blood circulation stability for MRI-guided tumor therapy 11(1) https://doi.org/10.1007/s40820-019-0292-y
  53. Moss et al. (2018) The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery 12(3) (pp. 223-236) https://doi.org/10.1080/17474124.2018.1399794
  54. Kotelevets et al. (2017) A squalene-based nanomedicine for oral treatment of colon cancer 77(11) (pp. 2964-2975) https://doi.org/10.1158/0008-5472.can-16-1741
  55. Liu et al. (2019) Nanozymes-engineered metal–organic frameworks for catalytic cascades-enhanced synergistic cancer therapy 19(8) (pp. 5674-5682) https://doi.org/10.1021/acs.nanolett.9b02253
  56. Gokila et al. (2017) Removal of the heavy metal ion chromiuim(VI) using chitosan and alginate nanocomposites 104(Pt B) (pp. 1459-1468) https://doi.org/10.1016/j.ijbiomac.2017.05.117
  57. Kumar and Koh (2012) Physiochemical, optical and biological activity of chitosan-chromone derivative for biomedical applications 13(5) (pp. 6102-6116) https://doi.org/10.3390/ijms13056102
  58. Eddya et al. (2020) A comparison of chitosan properties after extraction from shrimp shells by diluted and concentrated acids 6(2) (pp. e03486-e03486) https://doi.org/10.1016/j.heliyon.2020.e03486
  59. Alex et al. (1992) Studies of the effect of hydrogen bonding on the absorption and fluorescence spectra of all-trans-retinal at room temperature 70(3) (pp. 880-887) https://doi.org/10.1139/v92-117
  60. Papanikolas et al. (1990) Effects of hydrogen bonding on the low-lying electronic states of a model polyene aldehyde 112(5) (pp. 1912-1920) https://doi.org/10.1021/ja00161a041
  61. Brealey and Kasha (1955) The rôle of hydrogen bonding in the n → π* Blue-shift phenomenon1 77(17) (pp. 4462-4468) https://doi.org/10.1021/ja01622a006
  62. Karthikeyan et al. (2020) Investigation of kinetic drug release characteristics and in vitro evaluation of sustained-release matrix tablets of a selective COX-2 inhibitor for rheumatic diseases https://doi.org/10.1007/s12247-020-09459-9
  63. Mohammadnezhad et al. (2016) Preparation and evaluation of chitosan-coated eggshell particles as copper(II) biosorbent 57(4) (pp. 1693-1704) https://doi.org/10.1080/19443994.2014.976276
  64. Anraku et al. (2015) Slow-release of famotidine from tablets consisting of chitosan/sulfobutyl ether β-cyclodextrin composites 487(1–2) (pp. 142-147) https://doi.org/10.1016/j.ijpharm.2015.04.022
  65. Fu and Kao (2010) Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems 7(4) (pp. 429-444) https://doi.org/10.1517/17425241003602259
  66. Kanjickal and Lopina (2004) Modeling of drug release from polymeric delivery systems—a review 21(5) (pp. 345-386) https://doi.org/10.1615/critrevtherdrugcarriersyst.v21.i5.10
  67. Tavares et al. (2016) Modeling of the controlled release of betacarotene into anhydrous ethanol from microcapsules (pp. 25-35) https://doi.org/10.1016/j.onano.2016.05.001
  68. Higuchi (1961) Rate of release of medicaments from ointment bases containing drugs in suspension (pp. 874-875) https://doi.org/10.1002/jps.2600501018
  69. Nayak et al. (2009) Glutaraldehyde cross-linked chitosan microspheres for controlled delivery of zidovudine 26(3) (pp. 214-222) https://doi.org/10.1080/02652040802246325
  70. Quadir et al. (2003) Evaluation of hydrophobic materials as matrices for controlled-release drug delivery 16(2) (pp. 17-28)
  71. Yin et al. (2018) Pyraclostrobin-loaded poly (lactic-co-glycolic acid) nanospheres: preparation and characteristics 17(8) (pp. 1822-1832) https://doi.org/10.1016/S2095-3119(17)61839-2
  72. Wojcik-Pastuszka et al. (2019) Evaluation of the release kinetics of a pharmacologically active substance from model intra-articular implants replacing the cruciate ligaments of the knee 12(8) https://doi.org/10.3390/ma12081202
  73. Singhvi and Singh (2011) In vitro drug release characterization models 11(1) (pp. 77-84)
  74. Sriamornsak et al. (2007) Swelling and erosion of pectin matrix tablets and their impact on drug release mechanisms (pp. 211-219) https://doi.org/10.1016/j.ejpb.2006.12.014
  75. Gudiño et al. (2018) Modeling of non-Fickian diffusion and dissolution from a thin polymeric coating: an application to drug-eluting stents 114(3) (pp. 292-320) https://doi.org/10.1002/nme.5744
  76. Ostrowska-Czubenko et al. (2015) pH-responsive hydrogel membranes based on modified chitosan: water transport and kinetics of swelling 22(8) https://doi.org/10.1007/s10965-015-0786-3
  77. Srinatha et al. (2008) Ionic cross-linked chitosan beads for extended release of ciprofloxacin: in vitro characterization 70(1) (pp. 16-21) https://doi.org/10.4103/0250-474X.40326