10.1007/s40097-021-00391-z

Halloysite nanotubes filled with salicylic acid and sodium diclofenac: effects of vacuum pumping on loading and release properties

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  • Lorenzo Lisuzzo1,
  • Giuseppe Cavallaro*2,
  • Stefana Milioto2,
  • Giuseppe Lazzara2,
  1. Dipartimento di Fisica e Chimica “Emilio Segrè”, Università degli Studi di Palermo, Palermo, 90128, IT
  2. Dipartimento di Fisica e Chimica “Emilio Segrè”, Università degli Studi di Palermo, Palermo, 90128, IT Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali, INSTM, Florence, 50121, IT
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Published in Issue 02-02-2021

How to Cite

Lisuzzo, L., Cavallaro, G., Milioto, S., & Lazzara, G. (2021). Halloysite nanotubes filled with salicylic acid and sodium diclofenac: effects of vacuum pumping on loading and release properties. Journal of Nanostructure in Chemistry, 11(4 (December 2021). https://doi.org/10.1007/s40097-021-00391-z
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Abstract

Abstract In this work, we investigated the effects of the vacuum pumping on both the loading efficiencies and the release kinetics of halloysite nanotubes filled with drug molecules dissolved in ethanol. As model drugs, salicylic acid and sodium diclofenac were selected. For comparison, the loading of the drug molecules was conducted on platy kaolinite to explore the key role of the hollow tubular morphology on the filling mechanism of halloysite. The effects of the pressure conditions used in the loading protocol were interpreted and discussed on the basis of the thermodynamic results provided by Knudsen thermogravimetry, which demonstrated the ethanol confinement inside the halloysite cavity. Several techniques (TEM, FTIR spectroscopy, DLS and ζ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\zeta$$\end{document} -potential experiments) were employed to characterize the drug filled nanoclays. Besides, release kinetics of the drugs were studied and interpreted according to the loading mechanism. This work represents a further step for the development of nanotubular carriers with tunable release feature based on the loading protocol and drug localization into the carrier. Graphic abstract The filling efficiency of halloysite nanotubes is enhanced by the reduction of the pressure conditions used in the loading protocol.

Keywords

  • Halloysite nanotubes,
  • Sustained release,
  • Clay nanoparticles,
  • Drug loading,
  • Knudsen thermogravimetry
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