10.1007/s40097-021-00389-7

Wealth from by-products: an attempt to synthesize valuable gold nanoparticles from Brassica oleracea var. acephala cv. Galega stems

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  • Noelia González-Ballesteros1,
  • Javier Vidal-González1,
  • M. Carmen Rodríguez-Argüelles*1,
  1. Departamento de Química Inorgánica, CINBIO, Universidade de Vigo, Vigo, 36310, ES

Published in Issue 06-02-2021

How to Cite

González-Ballesteros, N., Vidal-González, J., & Rodríguez-Argüelles, M. C. (2021). Wealth from by-products: an attempt to synthesize valuable gold nanoparticles from Brassica oleracea var. acephala cv. Galega stems. Journal of Nanostructure in Chemistry, 11(4 (December 2021). https://doi.org/10.1007/s40097-021-00389-7
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Abstract

Abstract In the last years, the growth of the world’s population has resulted in an increase in the demand for food. Vegetables and fruit are essential for human nutrition but, regrettably, half the fruit and vegetables produced worldwide are wasted. The food industry generates tons of by-products during processing, for instance, peels, seeds and stems, which still possess bioactive compounds that can be of interest for other applications. The Brassicaceae species includes some of the most consumed vegetables worldwide known for their antioxidant activity associated with the presence of phenolic compounds. In this study, the stems of Brassica oleracea var. acephala cv. Galega (hereafter BG) were employed to prepare an aqueous extract. Then, its antioxidant potential was evaluated by means of the in vitro analysis of its ability to scavenge the free radical 1,1-diphenyl-2-picryl-hydrazyl (DPPH), the quantification of the total phenolic content and the analysis of the reducing power. Furthermore, the stem aqueous extract was employed to produce gold nanoparticles (AuNPs), acting as a reducing and stabilizing agent. AuNPs were characterized by UV–Visible and Fourier transform infrared spectroscopy. The size and shape of the nanoparticles was analyzed by the acquisition of transmission electron microscopy images, confirming the formation of spherical AuNPs with mean diameters of 25.08 ± 3.73 nm. Finally, three antioxidant assays were performed in the extract after the synthesis of AuNPs. The synthesis of AuNPs employing BG stem extract was revealed to be a good alternative for the revalorization of Brassica by-products. Graphical abstract

Keywords

  • Brassica oleracea,
  • Green synthesis,
  • Gold nanoparticles,
  • By-products,
  • Antioxidant activity

References

  1. Sertova (2020) Contribution of nanotechnology in animal and human health care (pp. 20091552-20091559)
  2. Falahati et al. (2020) Gold nanomaterials as key suppliers in biological and chemical sensing, catalysis, and medicine (pp. 129435-129462) https://doi.org/10.1016/j.bbagen.2019.129435
  3. Goddard et al. (2020) Active targeting of gold nanoparticles as cancer therapeutics (pp. 8774-8789) https://doi.org/10.1039/D0CS01121E
  4. Kang et al. (2020) State of the art biocompatible gold nanoparticles for cancer theragnosis (pp. 1-22) https://doi.org/10.3390/pharmaceutics12080701
  5. Rana et al. (2020) A comprehensive review on green synthesis of nature-inspired metal nanoparticles: mechanism, application and toxicity (pp. 122880-122880) https://doi.org/10.1016/j.jclepro.2020.122880
  6. Gour and Jain (2019) Advances in green synthesis of nanoparticles (pp. 844-851) https://doi.org/10.1080/21691401.2019.1577878
  7. Kalimuthu et al. (2020) Eco-friendly synthesis and biomedical applications of gold nanoparticles: a review (pp. 104296-104315) https://doi.org/10.1016/j.microc.2019.104296
  8. Lee et al. (2020) Recent developments in the facile bio-synthesis of gold nanoparticles (AuNPs) and their biomedical applications (pp. 275-300) https://doi.org/10.2147/IJN.S233789
  9. González-Ballesteros et al. (2020) Seaweeds: a promising bionanofactory for ecofriendly synthesis of gold and silver nanoparticles (pp. 507-541) Elsevier
  10. Augustine and Hasan (2020) Emerging applications of biocompatible phytosynthesized metal/metal oxide nanoparticles in healthcare (pp. 101516-101528) https://doi.org/10.1016/j.jddst.2020.101516
  11. Chandra et al. (2020) Medicinal plants: treasure trove for green synthesis of metallic nanoparticles and their biomedical applications (pp. 101518-101518) https://doi.org/10.1016/j.bcab.2020.101518
  12. Bao and Lan (2019) Advances in biosynthesis of noble metal nanoparticles mediated by photosynthetic organisms—a review (pp. 110519-110519) https://doi.org/10.1016/j.colsurfb.2019.110519
  13. Wang et al. (2017) Green synthesis of gold and silver nanoparticles using aqueous extract of Cibotium barometz root (pp. 1548-1555) https://doi.org/10.1080/21691401.2016.1260580
  14. Lafarga et al. (2018) Effect of steaming and sous vide processing on the total phenolic content, vitamin C and antioxidant potential of the genus Brassica (pp. 412-420) https://doi.org/10.1016/j.ifset.2018.04.008
  15. Liang et al. (2019) Valorizing cabbage (Brassica oleracea L. var. capitata) and capsicum (Capsicum annuum L.) wastes: in vitro health promoting activities (pp. 4696-4704) https://doi.org/10.1007/s13197-019-03912-5
  16. Amron and Konsue (2018) Antioxidant capacity and nitrosation inhibition of cruciferous vegetable extracts (pp. 65-73)
  17. Poveda et al. (2020) Brassica oleracea var. acephala (kale) improvement by biological activity of root endophytic fungi (pp. 1-12) https://doi.org/10.1038/s41598-020-77215-7
  18. Yadav and Kaur (2018) A review on exploring phytosynthesis of silver and gold nanoparticles using genus Brassica (pp. 165-177) https://doi.org/10.1504/IJNP.2018.094033
  19. Armesto et al. (2015) Physicochemical and phytochemical properties of two phenotypes of Galega kale (Brassica oleracea L. var. acephala cv. Galega) (pp. 439-448) https://doi.org/10.1111/jfbc.12151
  20. Fuente et al. (2020) Antiproliferative effect of bioaccessible fractions of four Brassicaceae microgreens on human colon cancer cells linked to their phytochemical composition (pp. 1-15) https://doi.org/10.3390/antiox9050368
  21. Armesto et al. (2018) Effects of different cooking methods on the antioxidant capacity and flavonoid, organic acid and mineral contents of Galega Kale (Brassica oleracea var. acephala cv. Galega) (pp. 136-149) https://doi.org/10.1080/09637486.2018.1482530
  22. Michalak et al. (2020) Fermented curly kale as a new source of gentisic and salicylic acids with antitumor potential (pp. 1-10) https://doi.org/10.1016/j.jff.2020.103866
  23. Jeong et al. (2020) Nanoencapsulation of synergistic antioxidant fruit and vegetable concentrates and their stability during in vitro digestion (pp. 1056-1063) https://doi.org/10.1002/jsfa.10110
  24. Šamec et al. (2018) Kale (Brassica oleracea var. acephala) as a superfood: review of the scientific evidence behind the statement (pp. 2411-2422) https://doi.org/10.1080/10408398.2018.1454400
  25. Fuente et al. (2019) Evaluation of the bioaccessibility of antioxidant bioactive compounds and minerals of four genotypes of Brassicaceae microgreens (pp. 1-16)
  26. Demirbas et al. (2019) Preparation of biocompatible and stable iron oxide nanoparticles using anthocyanin integrated hydrothermal method and their antimicrobial and antioxidant properties (pp. 1-8) https://doi.org/10.1088/2053-1591/ab540c
  27. Osuntokun et al. (2019) Green synthesis of ZnO nanoparticles using aqueous Brassica oleracea L. var. italica and the photocatalytic activity (pp. 444-457) https://doi.org/10.1080/17518253.2019.1687761
  28. Pillai et al. (2020) Green synthesis and characterization of zinc oxide nanoparticles with antibacterial and antifungal activity (pp. 1-8) https://doi.org/10.1016/j.molstruc.2020.128107
  29. Singh et al. (2018) Green silver nanoparticles from novel Brassicaceae cultivars with enhanced antimicrobial potential than earlier reported Brassicaceae members (pp. 1-11) https://doi.org/10.1016/j.jtemb.2018.01.001
  30. Kumar et al. (2020) Phytosynthesis of silver nanoparticles using andean cabbage: Structural characterization and its application (pp. 2079-2086) https://doi.org/10.1016/j.matpr.2020.01.327
  31. Imanzadeh and Hadi (2018) Brassica oleraceae, a versatile plant for green synthesis of silver nanoparticles (pp. 70-77)
  32. Kuppusamy et al. (2015) Intracellular biosynthesis of Au and Ag nanoparticles using ethanolic extract of Brassica oleracea L. and studies on their physicochemical and biological properties (pp. 151-157) https://doi.org/10.1016/j.jes.2014.06.050
  33. Ranjitham et al. (2013) In vitro evaluation of antioxidant, antimicrobial, anticancer activities and characterisation of Brassica oleracea var. bortrytis L. synthesized silver nanoparticles (pp. 239-251)
  34. Subramaniyan et al. (2018) A comparative study of biologically and chemically fabricated synthesized AgNPs’ supplementation with respect to heat-shock proteins, survival, and hatching rates of chicken embryos: an in ovo study (pp. 129-139) https://doi.org/10.1007/s10876-017-1319-5
  35. Sivakumar et al. (2017) Interaction of silver and gold nanoparticles in mammalian cancer: as real topical bullet for wound healing a comparative study (pp. 632-645) https://doi.org/10.1007/s11626-017-0150-5
  36. Sundaram et al. (2020) Antibacterial and anticancer potential of Brassica oleracea var. acephala using biosynthesised copper nanoparticles (pp. 677-684)
  37. Prasad et al. (2016) In-vitro evaluation of copper nanoparticles cytotoxicity on prostate cancer cell lines and their antioxidant, sensing and catalytic activity: One-pot green approach (pp. 375-382) https://doi.org/10.1016/j.jphotobiol.2016.06.008
  38. Piruthiviraj et al. (2016) Gold nanoparticles synthesized by Brassica oleracea (Broccoli) acting as antimicrobial agents against human pathogenic bacteria and fungi (pp. 467-473) https://doi.org/10.1007/s13204-015-0460-4
  39. Clemente et al. (2017) Gold nanoparticles from vegetable extracts using different plants from the market: a study on stability Shape and Toxicity (pp. 9777-9782)
  40. González-Ballesteros et al. (2017) Green synthesis of gold nanoparticles using brown seaweed Cystoseira baccata: its activity in colon cancer cells (pp. 190-198) https://doi.org/10.1016/j.colsurfb.2017.02.020
  41. González-Ballesteros et al. (2018) Harnessing the wine dregs: an approach towards a more sustainable synthesis of gold and silver nanoparticles (pp. 302-309) https://doi.org/10.1016/j.jphotobiol.2017.11.025
  42. Bhattacharjee (2016) DLS and zeta potential—what they are and what they are not? (pp. 337-351) https://doi.org/10.1016/j.jconrel.2016.06.017
  43. Carneiro-da-Cunha et al. (2011) Influence of concentration, ionic strength and pH on zeta potential and mean hydrodynamic diameter of edible polysaccharide solutions envisaged for multinanolayered films production (pp. 522-528) https://doi.org/10.1016/j.carbpol.2011.03.001
  44. Bishnoi et al. (2017) Wide-angle X-ray diffraction (WXRD): technique for characterization of nanomaterials and polymer nanocomposites (pp. 313-337) Elsevier https://doi.org/10.1016/B978-0-323-46141-2.00009-2
  45. Sotelo Pérez et al. (2016) Modification of leaf glucosinolate contents in Brassica oleracea by divergent selection and effect on expression of genes controlling glucosinolate pathway (pp. 1-12)
  46. Armesto et al. (2017) Impact of vacuum cooking and boiling and refrigerated storage on the quality of Galega kale (Brassica oleracea var. acephala cv. Galega) (pp. 267-277) https://doi.org/10.1016/j.lwt.2017.01.050
  47. Armesto et al. (2016) Effects of different cooking methods on some chemical and sensory properties of Galega kale (pp. 2071-2080) https://doi.org/10.1111/ijfs.13181