10.1007/s40097-021-00386-w

Synthesis and characterization of Au and Bi2O3 decorated Fe3O4@PAMAM dendrimer nanocomposites for medical applications

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  • Nurdan Kurnaz Yetim*1,
  • Fatma Kurşun Baysak1,
  • Mümin Mehmet Koç2,
  • Dilek Nartop3,
  1. Department of Chemistry, Faculty of Arts and Sciences, Kırklareli University, Kırklareli, TR
  2. School of Medical Service, Kırklareli University, Kırklareli, TR
  3. Department of Polymer Engineering, Faculty of Technology, Düzce University, Düzce, TR

Published in Issue 07-02-2021

How to Cite

Kurnaz Yetim, N., Kurşun Baysak, F., Koç, M. M., & Nartop, D. (2021). Synthesis and characterization of Au and Bi2O3 decorated Fe3O4@PAMAM dendrimer nanocomposites for medical applications. Journal of Nanostructure in Chemistry, 11(4 (December 2021). https://doi.org/10.1007/s40097-021-00386-w
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Abstract

Abstract Fe 3 O 4 magnetic nanoparticles were produced and covered with TEOS and APTES which were known to reduce the toxic properties of nanoparticles. Nanoparticles were functionalized second-generation PAMAM dendrimers and doped with Au and Bi 2 O 3 nanoparticles where Fe 3 O 4 @G2/Au/Bi 2 O 3 nanocomposites were obtained for potential multimodal imaging applications. Physicals structures of the nanocomposites were characterized using SEM and TEM which illustrate that nanoparticles were in composite form. Chemical composition of nanostructures was confirmed using EDX and FTIR. Magnetic characteristics were checked using VSM. It was seen that nanoparticles have superparamagnetic properties which indicate that nanocomposites have potential to be used in MRI and magnetic hyperthermia applications. X-ray imaging properties were confirmed using X-ray imaging and CT imaging. It was confirmed that doping nanoparticles with Au and Bi 2 O 3 nanoparticles significantly enhanced the X-ray tomography contrast enhancement properties which illustrate the theranostic properties of the nanocomposites.

Keywords

  • Fe3O4,
  • Magnetic nanoparticles,
  • PAMAM dendrimers,
  • TEOS,
  • Au,
  • Bi2O3,
  • Medical applications,
  • X-ray tomography

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