10.57647/jnsc.2026.1603.16

Mo₃C₂ Nanosheet-Enhanced Ditercalinium Biosensor: Insights into Redox and Intercalation Processes

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  • Zhangming Lei1,
  • Beibei Wang*2,
  1. Department of Urology, Quzhou People's Hospital; The Quzhou Affiliated Hospital, Wenzhou Medical University, Quzhou 324000, China
  2. Department of Pulmonary and Critical Care Medicine, Key Laboratory of Interventional Pulmonology of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

Received: 01-04-2026

Revised: 08-05-2026

Accepted: 29-05-2026

Published in Issue 30-06-2026

Copyright (c) 2026 Zhangming Lei, Beibei Wang (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Lei, Z., & Wang, B. (2026). Mo₃C₂ Nanosheet-Enhanced Ditercalinium Biosensor: Insights into Redox and Intercalation Processes. Journal of Nanostructure in Chemistry, 16(3 (June 2026). https://doi.org/10.57647/jnsc.2026.1603.16
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Abstract

In the present study, an electrochemical sensing framework was developed for identifying Ditercalinium, a therapeutic medication. The Mo3C2 MXene material was fabricated by precisely removing the aluminum component from Mo3AlC2 MAX structures and analyzed via SEM, TEM, XRD, XPS, BET, FT-IR plus EDS techniques. The data obtained from these analyses confirm that the nanolayers were successfully synthesized, showing the expected morphology and structure, indicating that the Mo3C2 MXene was effectively fabricated for further applications. A glassy carbon electrode (GCE) modified with Mo3C2 MXene and ds-DNA (Salmon sperm) showed higher sensitivity than that of bare GCE; therefore, the detection threshold for Ditercalinium became lower. Furthermore, molecular docking was performed to verify that bis-intercalation binds to ds-DNA molecules; the drug prefers to bind between C-G base pairs with an interaction free energy of -10.2 kcal/mol. The preferred binding mode contributes to the formation of a stable Ditercalinium-DNA complex and strengthened the anti-cancer effect via this mechanism.

Keywords

  • Ditercalinium,
  • DNA biosensor,
  • Docking study,
  • Mo3C2 MXene
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