10.57647/jnsc.2025.1505.19

A New Heterogeneous PMO@MXene Catalyst for One-Pot Synthesis of Substituted 5-amino-3-(aryl)-1-phenyl-1H-pyrazole-4-carbonitrile Derivatives

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  • Safa Hanifi1,
  • Farhad Shirini*1,
  • Bahram Ramezanzadeh2,
  • Hassan Tajik1,
  1. Department of Organic Chemistry, Faculty of Chemistry, University of Guilan, Rasht, Iran
  2. Department of Surface Coating and Corrosion, Institute for Color Science and Technology, Tehran, Iran

Received: 02-07-2025

Revised: 12-08-2025

Accepted: 04-10-2025

Published in Issue 17-10-2025

Copyright (c) 2025 Safa Hnaif, Farhad Shirini, Bahram Ramezanzadeh, Hassan Tajik (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Hanifi, S., Shirini, F., Ramezanzadeh, B., & Tajik, H. (2025). A New Heterogeneous PMO@MXene Catalyst for One-Pot Synthesis of Substituted 5-amino-3-(aryl)-1-phenyl-1H-pyrazole-4-carbonitrile Derivatives. Journal of Nanostructure in Chemistry, 15(5 (October 2025). https://doi.org/10.57647/jnsc.2025.1505.19
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Abstract

In this study, we report the development of a novel and efficient MXene-based heterogeneous catalyst, PMO@MXene, for the green  synthesis of 5-amino-3-(aryl)-1-phenyl-1H-pyrazole-4-carbonitrile derivatives. By integrating periodic mesoporous organosilica (PMO) into  multilayered MXene, a hybrid nanocomposite was achieved that benefits from the high surface area and electrical conductivity of MXene  along with the welldefined mesoporosity of PMO. This unique synergy enabled highly efficient catalytic performance under mild, eco-friendly conditions, requiring only a small amount of catalyst and allowing for easy recovery and reuse with minimal loss of activity. The  pyrazole derivatives, known for their potential pharmaceutical relevance, were obtained in excellent yields and characterized using  standard spectroscopic techniques. Importantly, this work highlights the potential of the PMO@MXene as a sustainable and recyclable  heterogeneous catalyst platform for the synthesis of biologically significant heterocyclic compounds.

Keywords

  • MXene,
  • Periodic mesoporous organosillica,
  • Pyrazole,
  • Ti3AlC2,
  • PMO,
  • Heterogeneous catalyst,
  • Nanocomposite
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